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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

As discussed earlier, E2A gene products are critical for B-cell development. Consistent with this, E2A serves as a transcriptional activator of many genes involved in B-cell commitment and antigen receptor generation. Additionally, E2A acts as a transcriptional repressor of certain genes in pre-B cells [1].

References
  1. Greenbaum S et al. Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. J. Biol. Chem., 279(43):45028-35. (PMID 15310760)
    Targets (author curated)
      Target gene TF complex Effect References GO terms (biological process)
    1 Igll1 (none provided)
    (unknown)
    (none) (no terms found)
    2 Cdkn1a (none provided)
    (unknown)
    (none) (no terms found)
    3 Cd79a (mouse) (none provided)
    (unknown)
    (none) 5 terms found
    4 Ebf1 (mouse) (none provided)
    (unknown)
    (none) 6 terms found
    5 Fgfr2 (mouse) (none provided)
    15310760 95 terms found
    positive regulation of Wnt receptor signaling pathway through beta-catenin (IMP, 16720875)   positive regulation of Wnt receptor signaling pathway through beta-catenin (IGI, 18533146)   cellular response to protein stimulus (IDA, 18231602)   positive regulation of ERK1 and ERK2 cascade (IGI, 17202188)   regulation of ERK1 and ERK2 cascade (IMP, 16989802)   mesenchymal cell proliferation involved in lung development (IMP, 16989802)   mesenchymal cell differentiation involved in lung development (IGI, 16989802)   regulation of morphogenesis of a branching structure (IMP, 17202188)   regulation of branching involved in prostate gland morphogenesis (IMP, 17202188)   branching involved in embryonic placenta morphogenesis (IMP, 9435295)   branch elongation involved in salivary gland morphogenesis (IMP, 15972105)   branch elongation involved in salivary gland morphogenesis (IGI, 15972105)   epithelial cell proliferation involved in salivary gland morphogenesis (IMP, 15972105)   epithelial cell proliferation involved in salivary gland morphogenesis (IGI, 15972105)   mammary gland bud formation (IMP, 11782400)   lateral sprouting from an epithelium (IMP, 12666202)   fibroblast growth factor receptor signaling pathway involved in mammary gland specification (IMP, 16720875)   squamous basal epithelial stem cell differentiation involved in prostate gland acinus development (IMP, 17215304)   prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (IMP, 17215304)   prostate epithelial cord elongation (IMP, 17215304)   prostate gland morphogenesis (IMP, 18184727)   positive regulation of epithelial cell proliferation involved in lung morphogenesis (IMP, 16989802)   lung-associated mesenchyme development (IMP, 16989802)   lung-associated mesenchyme development (IGI, 18533146)   lung lobe morphogenesis (IMP, 16989802)   bud elongation involved in lung branching (IMP, 16989802)   branching involved in salivary gland morphogenesis (IMP, 11731698)   branching involved in prostate gland morphogenesis (IMP, 12666202)   bone morphogenesis (IMP, 10518547)   bone development (IMP, 16989802)   limb bud formation (IMP, 9435295)   positive regulation of cardiac muscle cell proliferation (IGI, 15621532)   ventricular cardiac muscle tissue morphogenesis (IMP, 16687131)   positive regulation of cell division (IMP, 14530295)   regulation of smooth muscle cell differentiation (IMP, 16989802)   negative regulation of epithelial cell proliferation   positive regulation of epithelial cell proliferation (IGI, 15972105)   regulation of epithelial cell proliferation (IMP, 18184727)   epithelial cell proliferation (IMP, 15843416)   mesenchymal cell differentiation (IGI, 16442091)   branching morphogenesis of a nerve (IMP, 17951031)   epidermis morphogenesis (IMP, 14530295)   positive regulation of smooth muscle cell proliferation   reproductive structure development (IMP, 12666202)   embryonic organ development (IMP, 9435295)   gut development (IMP, 15234214)   embryonic organ morphogenesis (IMP, 15843416)   embryonic digestive tract morphogenesis (IMP, 16618415)   lung alveolus development (IMP, 16989802)   lung alveolus development (IGI, 16989802)   cell fate commitment (IDA, 15509736)   odontogenesis (IMP, 17951031)   inner ear morphogenesis (IMP, 10934262)   regulation of cell proliferation (IMP, 12756187)   regulation of fibroblast growth factor receptor signaling pathway (IMP, 16989802)   regulation of multicellular organism growth (IMP, 9435295)   organ growth (IMP, 16618415)   multicellular organism growth (IMP, 16989802)   lacrimal gland development (IMP, 10821755)   hair follicle morphogenesis (IMP, 14530295)   otic vesicle formation (IMP, 9435295)   midbrain development (IGI, 17687036)   epithelial cell differentiation (IMP, 16618415)   lung development (IMP, 10518547)   lung development (IGI, 16540513)   bone mineralization (IMP, 12756187)   positive regulation of Wnt receptor signaling pathway (IMP, 16989802)   gland morphogenesis (IMP, 17202188)   morphogenesis of embryonic epithelium (IMP, 15843416)   negative regulation of gene-specific transcription from RNA polymerase II promoter (IMP, 16989802)   positive regulation of gene-specific transcription from RNA polymerase II promoter (IMP, 16989802)   regulation of cell fate commitment (IMP, 16989802)   organ morphogenesis (IMP, 12666202)   embryonic pattern specification (IMP, 16618415)   post-embryonic development (IMP, 16989802)   regulation of smoothened signaling pathway (IMP, 16618415)   fibroblast growth factor receptor signaling pathway   fibroblast growth factor receptor signaling pathway (IMP, 9435295)   fibroblast growth factor receptor signaling pathway (IGI, 16778080)   fibroblast growth factor receptor signaling pathway   positive regulation of cell proliferation   positive regulation of cell proliferation (IMP, 15199404)   positive regulation of cell proliferation (IGI, 16778080)   positive regulation of cell proliferation   axonogenesis (IMP, 17951031)   cell-cell signaling (IMP, 15199404)   protein amino acid phosphorylation   membranous septum morphogenesis (IMP, 16687131)   outflow tract septum morphogenesis (IMP, 16687131)   positive regulation of mesenchymal cell proliferation (IGI, 16540513)   epithelial to mesenchymal transition   in utero embryonic development (IMP, 9435295)   in utero embryonic development (IGI, 17687036)   ureteric bud development (IGI, 16442091)   angiogenesis (IGI, 16778080)  
    6 Gfi1b (mouse) (none provided)
    (unknown)
    17272506 3 terms found
    7 Neurod1 (mouse) (none provided)
    (unknown)
    (none) 19 terms found
    8 Nfil3 (mouse) (none provided)
    15310760 4 terms found
    9 Pax5 (mouse) (none provided)
    (unknown)
    (none) 11 terms found
    10 Vpreb1 (mouse) (none provided)
    (unknown)
    (none) 9 terms found
    Targets (automatically populated)
    About this section
    Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
      Target gene TF complex Effect References GO terms (biological process)
    1 Gck (mouse) pazar NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    12540614 28 terms found
    2 Ins2 (mouse) pazar NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    7774807 12 terms found
    3 INS2_RAT (rat) pazar NEUROD1_MOUSE/TCF3_MOUSE
    Neurod1_MOUSE
    (unknown)
    15793245 54 terms found
    negative regulation of respiratory burst involved in inflammatory response   fatty acid homeostasis   positive regulation of protein kinase B signaling cascade   positive regulation of peptidyl-tyrosine phosphorylation   positive regulation of NF-kappaB transcription factor activity   positive regulation of cytokine secretion   negative regulation of protein secretion   alpha-beta T cell activation   regulation of protein secretion   positive regulation of insulin receptor signaling pathway   negative regulation of fatty acid metabolic process   positive regulation of glucose import   positive regulation of mitosis   negative regulation of proteolysis   positive regulation of glycolysis   negative regulation of glycogen catabolic process   respiratory burst   positive regulation of DNA replication   positive regulation of glycogen biosynthetic process   positive regulation of MAPKKK cascade   regulation of apoptosis   regulation of apoptosis   glucose homeostasis   regulation of phosphorylation   regulation of phosphorylation   wound healing   negative regulation of protein catabolic process   negative regulation of NAD(P)H oxidase activity   regulation of protein localization   positive regulation of cellular protein metabolic process   activation of protein kinase B activity   regulation of transmembrane transporter activity   lipid catabolic process   lipid catabolic process   glucose transport   positive regulation of phosphoinositide 3-kinase cascade   insulin receptor signaling pathway   insulin receptor signaling pathway   positive regulation of cell proliferation   biological_process   activation of JUN kinase activity   G-protein coupled receptor protein signaling pathway   ER overload response   ER overload response   acute-phase response   regulation of cellular amino acid metabolic process   glucose metabolic process   glucose metabolic process   carbohydrate metabolic process   negative regulation of acute inflammatory response   activation of MAPK activity   MAPKKK cascade   negative regulation of transcription from RNA polymerase II promoter   negative regulation of transcription from RNA polymerase II promoter  
    4 Insm1 (mouse) pazar NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    12890672 2 terms found
    5 Nanog (mouse) pazar TCF3
    (unknown)
    16894029 22 terms found
    6 Nnat (mouse) pazar Neurod1_MOUSE
    NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    15793245 4 terms found
    7 Pax6 (mouse) pazar NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    12962539 57 terms found
    cell differentiation (IMP, 15031110)   cell differentiation   regulation of neuron differentiation   regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment (IMP, 9230312)   pituitary gland development (IMP, 10588713)   regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification (IMP, 9230312)   regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification (IMP, 9230312)   commitment of a neuronal cell to a specific type of neuron in the forebrain (IMP, 11124115)   forebrain-midbrain boundary formation (IMP, 9169845)   forebrain dorsal/ventral pattern formation (IMP, 11124115)   forebrain anterior/posterior pattern formation (IMP, 9169845)   oligodendrocyte cell fate specification (IMP, 9828088)   pallium development (IMP, 11124115)   regulation of gene expression (IMP, 16919471)   anterior/posterior pattern formation (IMP, 12196586)   dorsal/ventral pattern formation (IMP, 15548580)   anterior/posterior pattern formation (IGI, 15917450)   negative regulation of cell proliferation (IMP, 15548580)   dorsal/ventral axis specification (IMP, 10588713)   salivary gland morphogenesis (IMP, 11731698)   brain development (IMP, 10409504)   brain development   axon guidance (IMP, 14586016)   axonogenesis (IMP, 15514979)   smoothened signaling pathway (IDA, 18590716)   multicellular organismal development   regulation of transcription   cell fate commitment (IMP, 15878992)   cell fate commitment (IGI, 15229646)   camera-type eye development (IMP, 11069887)   camera-type eye development (IGI, 12183364)   eye photoreceptor cell development (IMP, 12648492)   positive regulation of cell fate specification   lacrimal gland development (IMP, 10821755)   protein localization in organelle (IMP, 16024294)   hindbrain development   forebrain development (IMP, 15548580)   positive regulation of epithelial cell differentiation (IMP, 16080917)   regulation of cell migration (IMP, 10409504)   keratinocyte differentiation (IMP, 16080917)   transcription from RNA polymerase II promoter   regulation of transcription, DNA-dependent   regulation of transcription, DNA-dependent (TAS, 10197584)   transcription   lens development in camera-type eye (IMP, 6877261)   neuron migration   positive regulation of neuroblast proliferation (IMP, 18287938)   neuron migration (IMP, 15758185)   cell fate determination (IMP, 12756174)   regulation of neurogenesis (IMP, 15548580)   regulation of neurogenesis   negative regulation of epithelial cell proliferation (IMP, 16080917)   regulation of epithelial cell proliferation   astrocyte differentiation (IMP, 19258013)   regulation of timing of cell differentiation (IMP, 9828088)   positive regulation of transcription from RNA polymerase II promoter (IDA, 15905411)   negative regulation of neuron differentiation (IGI, 16950124)  
    8 Pdx1 (mouse) pazar NEUROD1_MOUSE/TCF3_MOUSE
    (unknown)
    9111329 33 terms found
    protein heterooligomerization   stem cell differentiation   positive regulation of transcription from RNA polymerase II promoter   positive regulation of transcription   positive regulation of transcription from RNA polymerase II promoter (IDA, 15486225)   regulation of transcription   positive regulation of DNA binding   glucose homeostasis (IMP, 18155690)   glucose homeostasis   regulation of cell proliferation (IDA, 12488434)   positive regulation of insulin secretion   endocrine pancreas development (IMP, 18155690)   exocrine pancreas development (IMP, 16126192)   pancreas development (IMP, 16418487)   cell differentiation   cell differentiation (IMP, 16418487)   negative regulation of transcription   morphogenesis of embryonic epithelium (IMP, 8625829)   positive regulation of cell death   response to glucose stimulus   negative regulation of cell proliferation (IMP, 18155690)   positive regulation of cell proliferation   positive regulation of cell proliferation (IMP, 18155690)   multicellular organismal development   transcription from RNA polymerase II promoter   smoothened signaling pathway   regulation of transcription from RNA polymerase II promoter (IMP, 12972592)   regulation of transcription, DNA-dependent   regulation of transcription, DNA-dependent (IDA, 12368292)   transcription   transcription, DNA-dependent   glucose metabolic process (IDA, 12904469)   negative regulation of transcription from RNA polymerase II promoter (IDA, 17056599)  
    9 Pou5f1 (mouse) pazar TCF3 M3
    (unknown)
    18467660 23 terms found