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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Genetics

E2A proteins are involved in many disease phenotypes. E2A-null mice show a high incidence of T-lymphoblastic lymphoma. In these lympomas, ectopic expression of E47 or E12 promotes apoptosis of the neoplastic cells, confirming the anti-proliferative effects of E2A gene products.

MeSH cloud (automatically populated)
About this section
The MeSH cloud below displays MeSH terms that are associated with this transcription factor. The physical size of the terms reflect the significance of their association with the transcription factor as determined by the Fisher's Exact Test. It should be noted that these associations do not necessarily imply a positive correlation between the described MeSH term and this transcription factor. For instance, if the MeSH term "apoptosis" occurs, it may indicate that this transcription factor can induce apoptosis (positive correlation), or prevent apoptosis (negative correlation). Methods: The transcription factor is mapped to a set of Pubmed publications through the gene-to-pubmed association as provided by NCBI. Then, a collection of MeSH terms associated with the papers are compiled, along with the frequency of each MeSH term. The Fisher's Exact Test is conducted on the frequency of each term in the collection, versus its average frequency, to determine its significance in the collection. More information on MeSH can be found on the MeSH homepage.
MeSH term Fisher's exact p-value
1 Lymphoma, T-Cell 1.1 x 10-7
2 Nail-Patella Syndrome 0.0037
3 Myopathies, Structural, Congenital 0.0055
4 Chromosome Breakage 0.016
5 Chromosome Inversion 0.030
6 Lymphopenia 0.035
7 Leukemia, Erythroblastic, Acute 0.047
MeSH term Fisher's exact p-value
1 Lymphoma, T-Cell 1.1 x 10-7
2 Thymus Neoplasms 1.2 x 10-6
3 Cell Transformation, Neoplastic 1.3 x 10-5
4 Lymphoma 2.4 x 10-5
5 Immunoproliferative Disorders 0.00023
6 Lymphoma, Non-Hodgkin 0.00047
7 Lymphoproliferative Disorders 0.00062
8 Lymphatic Diseases 0.0014
9 Neoplastic Processes 0.0031
10 Nail-Patella Syndrome 0.0037
11 Myopathies, Structural, Congenital 0.0055
12 Chromosome Breakage 0.016
13 Chromosome Inversion 0.030
14 Hemic and Lymphatic Diseases 0.031
15 Lymphopenia 0.035
16 Leukemia, Erythroblastic, Acute 0.047
MGI mammalian phenotype terms (automatically populated)