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Homo sapiens
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Mus musculus
Homo sapiens
Mus musculus
Transcription Factor Encyclopedia  BETA
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No annotation is available in this section for this article. The content below is taken from a related TF, PAX8 (Homo sapiens).

In mouse, Pax8 is expressed in the developing central nervous system, kidney, and thyroid. It is the only member of the family expressed in the thyroid tissue and it has been demonstrated to be a master gene for the regulation of the thyroid differentiated phenotype and for the transcriptional activation of the differentiation markers such as thyroglobulin, thyroperoxidase, and sodium/iodide symporter[1][2][3][4][5][6][7]. In addition, the Pax2 and Pax8 transcription factors are central regulators of kidney development[8] and in terms of function Pax2/8 genes are necessary and sufficient to induce the nephric lineage. It has been demonstrated that Pax8 is able to regulate the expression of GATA3[9], a transcription factor gene associated with hypoparathyroidism, deafness and renal anomaly (HDR) syndrome, of WT1[10][11][12] and of bcl-2[13], the latter suggesting that suppression of apoptosis is an important event in the development and maintenance of renal tubular epithelial structures. Recently, it has been demonstrated that PAX8 is able to coordinately transactivate the promoter of both the telomerase catalytic subunit (hTERT) and the telomerase RNA component (hTR) genes suggesting a possibile role of Pax8 in telomerase regulation[14].

  1. Zannini M et al. Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters. Mol. Cell. Biol., 12(9):4230-41. (PMID 1508216)
  2. Damante G et al. A unique combination of transcription factors controls differentiation of thyroid cells. Prog. Nucleic Acid Res. Mol. Biol., 66:307-56. (PMID 11051768)
  3. Schmitt TL et al. Transcriptional regulation of the human sodium/iodide symporter gene by Pax8 and TTF-1. Exp. Clin. Endocrinol. Diabetes, 109(1):27-31. (PMID 11573135)
  4. Kang HC et al. Pax-8 is essential for regulation of the thyroglobulin gene by transforming growth factor-beta1. Endocrinology, 142(1):267-75. (PMID 11145590)
  5. Espinoza CR et al. Thyroid transcription factor 1 and Pax8 synergistically activate the promoter of the human thyroglobulin gene. J. Mol. Endocrinol., 27(1):59-67. (PMID 11463576)
  6. Ohno M et al. The paired-domain transcription factor Pax8 binds to the upstream enhancer of the rat sodium/iodide symporter gene and participates in both thyroid-specific and cyclic-AMP-dependent transcription. Mol. Cell. Biol., 19(3):2051-60. (PMID 10022892)
  7. Fabbro D et al. Pax-8 protein levels regulate thyroglobulin gene expression. J. Mol. Endocrinol., 21(3):347-54. (PMID 9845675)
  1. Narlis M et al. Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney. J. Am. Soc. Nephrol., 18(4):1121-9. (PMID 17314325)
  2. Grote D et al. Pax 2/8-regulated Gata 3 expression is necessary for morphogenesis and guidance of the nephric duct in the developing kidney. Development, 133(1):53-61. (PMID 16319112)
  3. Siehl JM et al. Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias. Br. J. Haematol., 123(2):235-42. (PMID 14531904)
  4. Fraizer GC et al. PAX 8 regulates human WT1 transcription through a novel DNA binding site. J. Biol. Chem., 272(49):30678-87. (PMID 9388203)
  5. Dehbi M and Pelletier J. PAX8-mediated activation of the wt1 tumor suppressor gene. EMBO J., 15(16):4297-306. (PMID 8861958)
  6. Hewitt SM et al. Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8. Anticancer Res., 17(5A):3211-5. (PMID 9413150)
  7. Chen YJ et al. PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res., 68(14):5724-32. (PMID 18632625)
Targets (author curated)
  Target gene TF complex Effect References GO terms (biological process)
1 BCL2 (human) (none provided)
9413150 116 terms found
apoptosis in response to endoplasmic reticulum stress (IDA, 15776018)   regulation of calcium ion transport (IDA, 8022822)   negative regulation of mitochondrial depolarization (TAS, 9027314)   regulation of mitochondrial membrane potential (ISS, 9843949)   response to protein stimulus   regulation of cell cycle   response to folic acid   defense response to virus (IDA, 10620603)   response to corticosterone stimulus   neuron apoptosis (TAS, 16167175)   pigment granule organization   homeostasis of number of cells within a tissue   oocyte development   positive regulation of skeletal muscle fiber development   developmental growth   thymus development   spleen development   positive regulation of developmental pigmentation   focal adhesion assembly   regulation of mitochondrial membrane permeability (ISS, 9843949)   response to copper ion   negative regulation of retinal cell programmed cell death   negative regulation of mitotic cell cycle   positive regulation of melanocyte differentiation   response to ethanol   regulation of viral genome replication   response to estrogen stimulus   ear development   negative regulation of neuron apoptosis (IDA, 7546744)   regulation of protein heterodimerization activity (IDA, 9111042)   regulation of protein homodimerization activity (IDA, 9111042)   CD8-positive, alpha-beta T cell lineage commitment   positive regulation of catalytic activity   negative regulation of apoptosis (IDA, 15776018)   T cell homeostasis   response to hydrogen peroxide   response to drug (IDA, 36599)   B cell proliferation (IDA, 1373874)   positive regulation of multicellular organism growth   organ growth   glial cell apoptosis   response to nicotine (IDA, 12421819)   response to cytokine stimulus (IDA, 9184696)   negative regulation of osteoblast proliferation   response to L-ascorbic acid   positive regulation of peptidyl-serine phosphorylation   T cell differentiation in the thymus   negative regulation of myeloid cell apoptosis   regulation of protein localization   response to insulin stimulus   negative regulation of cellular pH reduction (IDA, 10506221)   glomerulus development   endoplasmic reticulum calcium ion homeostasis   regulation of protein stability   axon regeneration   hair follicle morphogenesis   negative regulation of cell migration   response to caffeine   positive regulation of cell growth (IDA, 8022822)   negative regulation of cell growth   negative regulation of ossification   hemopoiesis   gland morphogenesis   cochlear nucleus development   peptidyl-threonine phosphorylation   cell-cell adhesion   positive regulation of smooth muscle cell migration   positive regulation of neuron maturation   mesenchymal cell development   regulation of glycoprotein biosynthetic process   negative regulation of calcium ion transport into cytosol   regulation of gene expression   response to gamma radiation   response to aluminum ion   response to UV-B   response to iron ion (IDA, 11264898)   response to inorganic substance   organ morphogenesis   response to toxin (IDA, 16717086)   post-embryonic development   response to external stimulus   response to heat   response to radiation (NAS, 15799693)   male gonad development   activation of pro-apoptotic gene products (EXP, 15231831)   positive regulation of cell proliferation   cell death (IDA, 36599)   response to nutrient   cell aging   female pregnancy (NAS, 11530860)   actin filament organization   humoral immune response (TAS, 1908951)   response to oxidative stress   anti-apoptosis (IDA, 10620603)   regulation of nitrogen utilization   oxygen and reactive oxygen species metabolic process   melanin metabolic process   protein amino acid dephosphorylation   renal system process   immune system development   T cell lineage commitment   B cell lineage commitment   lymphoid progenitor cell differentiation   regulation of cell-matrix adhesion   release of cytochrome c from mitochondria (NAS, 9027314)   release of cytochrome c from mitochondria (ISS, 9843949)   B cell homeostasis   response to hypoxia   behavioral fear response   branching involved in ureteric bud morphogenesis   ureteric bud development   metanephros development   ovarian follicle development   cell morphogenesis   protein polyubiquitination (IDA, 16717086)   G1/S transition of mitotic cell cycle  
2 GATA3 (human) (none provided)
16319112 5 terms found
3 Slc5a5 (rat) (none provided)
10022892 5 terms found
4 SLC5A5 (human) (none provided)
15319451 5 terms found
5 TERT (human) (none provided)
18632625 6 terms found
6 TG (human) (none provided)
1508216 9845675 6 terms found
7 Tg (rat) (none provided)
1508216 6 terms found
8 Tpo (rat) (none provided)
1508216 5 terms found
9 TPO (human) (none provided)
1508216 4 terms found
10 WT1 (human) (none provided)
8861958 9388203 32 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at
  Target gene TF complex Effect References GO terms (biological process)
1 Tg (mouse) pazar PAX8_MOUSE
1508216 7 terms found
2 Tpo (mouse) pazar PAX8_HUMAN
1508216 4 terms found
3 Wt1 (mouse) pazar PAX8_MOUSE
886158 32 terms found
mesenchymal to epithelial transition (IMP, 9927198)   positive regulation of transcription from RNA polymerase II promoter   positive regulation of transcription from RNA polymerase II promoter (IDA, 16264195)   positive regulation of transcription (ISS, 14701728)   positive regulation of transcription (IMP, 11912180)   regulation of transcription   positive regulation of transcription (IDA, 8530339)   negative regulation of apoptosis (IMP, 10101119)   camera-type eye development (IMP, 11889045)   glomerulus development (IMP, 10101119)   epithelial cell differentiation (IMP, 9927198)   male genitalia development (IMP, 10077614)   adrenal gland development (IMP, 10101119)   negative regulation of transcription (ISS, 14701728)   negative regulation of transcription (IDA, 8530339)   tissue development (IMP, 15716344)   male gonad development (IMP, 15063178)   RNA splicing (IDA, 9784496)   sex determination (IMP, 11509181)   germ cell development (IMP, 15063178)   heart development (IMP, 10101119)   regulation of transcription from RNA polymerase II promoter (IDA, 12151099)   regulation of transcription, DNA-dependent (IDA, 11889045)   regulation of transcription, DNA-dependent   transcription   mesonephros development (IMP, 9118800)   kidney development (IMP, 11912180)   branching involved in ureteric bud morphogenesis (IMP, 10101119)   ureteric bud development (IMP, 10322633)   vasculogenesis (IMP, 16264195)   metanephros development (IMP, 10322633)   negative regulation of transcription from RNA polymerase II promoter (ISO, 7585606)