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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview
No annotation is available in this section for this article. The content below is taken from a related TF, FOSL1 (Homo sapiens).

FOSL1 based AP-1 complex binds to the TPA response element (TRE or AP-1 site), with a general consensus sequence 5'-TGAG/CTA-3' [1]. In addition, FOSL1 interacts with other leucine zipper proteins and differentially regulates gene expression (see TFBS tab for more details). Several studies have shown that FOSL1 regulates gene expression involved in cell cycle progression, cell motility and invasion in several cancer cell types [2][3]. Some of them include: Plaur, cyclin D1, cyclin A, MMP-1, MMP-2, MMP-9, elastin, Il-6, HMOX-1, SPRR1B, involucrin, PAI-1, HMGI (Y), uPA, p14/p19ARF, and other genes [4](see table below).

References
  1. Cohen DR et al. The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev., 3(2):173-84. (PMID 2497053)
  2. Milde-Langosch K. The Fos family of transcription factors and their role in tumourigenesis. Eur. J. Cancer, 41(16):2449-61. (PMID 16199154)
  1. Kustikova O et al. Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol. Cell. Biol., 18(12):7095-105. (PMID 9819396)
  2. Reddy SP and Mossman BT. Role and regulation of activator protein-1 in toxicant-induced responses of the lung. Am. J. Physiol. Lung Cell Mol. Physiol., 283(6):L1161-78. (PMID 12424143)
Targets (author curated)
No annotation is available in this section for this article. The content below is taken from a related TF, FOSL1 (Homo sapiens).
  Target gene TF complex Effect References GO terms (biological process)
1 Ccna2 (mouse) AP-1
(unknown)
17347653 6 terms found
2 Ccnd1 (mouse) AP-1
(unknown)
15143165 19 terms found
3 Cd44 (rat) (none provided)
(unknown)
18096084 22 terms found
4 CDKN2A (human) AP-1
(unknown)
15688012 34 terms found
positive regulation of cell cycle arrest (IDA, 9529249)   negative regulation of ubiquitin-protein ligase activity   protein stabilization (IDA, 10360174)   regulation of protein export from nucleus (IMP, 10360174)   somatic stem cell division   regulation of transcription   negative regulation of cyclin-dependent protein kinase activity (IDA, 8259215)   positive regulation of DNA damage response, signal transduction by p53 class mediator (IDA, 9529249)   negative regulation of phosphorylation (IDA, 10208428)   negative regulation of NF-kappaB transcription factor activity (IDA, 10353611)   negative regulation of immature T cell proliferation in the thymus   protein destabilization (IDA, 9529249)   regulation of protein stability   negative regulation of cell growth (IDA, 10208428)   negative regulation of B cell proliferation   regulation of G2/M transition of mitotic cell cycle (IMP, 15582998)   senescence (IMP, 14720514)   senescence (IDA, 15149599)   apoptotic mitochondrial changes (IMP, 12082630)   negative regulation of cell proliferation (IMP, 16243918)   negative regulation of cell proliferation (IDA, 15149599)   Ras protein signal transduction (IEP, 9054499)   cell cycle arrest (IMP, 16243918)   cell cycle arrest (IDA, 15149599)   activation of caspase activity (IMP, 12082630)   cell cycle   induction of apoptosis (IMP, 12082630)   induction of apoptosis (IDA, 10208428)   rRNA processing   negative regulation of protein kinase activity (IMP, 15582998)   DNA fragmentation involved in apoptotic nuclear change (IMP, 12082630)   negative regulation of cell-matrix adhesion (IMP, 10205165)   G1/S transition of mitotic cell cycle (IDA, 10208428)   cell cycle checkpoint (IMP, 16243918)  
5 ELN (human) AP-1
(unknown)
1155758 4 terms found
6 IL6 (human) AP-1
(unknown)
10405202 49 terms found
glucagon secretion (ISS, 18719127)   interleukin-6-mediated signaling pathway (IDA, 12552091)   defense response to virus (IDA, 3023045)   response to glucocorticoid stimulus (IDA, 10443688)   positive regulation of NF-kappaB transcription factor activity (IDA, 12419823)   positive regulation of transcription factor activity (IDA, 7749983)   positive regulation of immunoglobulin secretion (IDA, 3491322)   positive regulation of B cell activation (IDA, 3491322)   defense response to Gram-positive bacterium (IEP, 16034137)   defense response to Gram-negative bacterium (IEP, 16034137)   positive regulation of peptidyl-tyrosine phosphorylation (IDA, 7508917)   positive regulation of smooth muscle cell proliferation (IDA, 10510402)   positive regulation of JAK-STAT cascade (IDA, 12419823)   positive regulation of transcription from RNA polymerase II promoter (IDA, 7508917)   regulation of angiogenesis (IC, 8557680)   positive regulation of anti-apoptosis (IMP, 18719127)   positive regulation of translation (IDA, 16732314)   positive regulation of osteoblast differentiation (TAS, 12372336)   negative regulation of chemokine biosynthetic process   positive regulation of MAPKKK cascade (IDA, 7508917)   negative regulation of apoptosis (IDA, 7595060)   positive regulation of gene-specific transcription (IDA, 7749983)   regulation of apoptosis (IDA, 9949178)   positive regulation of tyrosine phosphorylation of Stat3 protein (IDA, 12643274)   positive regulation of T cell proliferation (IDA, 3130269)   positive regulation of peptidyl-serine phosphorylation (IDA, 7508917)   negative regulation of collagen biosynthetic process (IDA, 12419823)   positive regulation of interleukin-6 production (IDA, 10510402)   positive regulation of chemokine production (IMP, 16034137)   response to peptidoglycan (IEP, 16034137)   positive regulation of chemokine production (IDA, 10510402)   neuron projection development (IMP, 3264880)   endocrine pancreas development (ISS, 18719127)   platelet activation (TAS, 7831669)   cytokine-mediated signaling pathway (IDA, 12643274)   regulation of vascular endothelial growth factor production (IDA, 8557680)   negative regulation of cell proliferation (TAS, 3023045)   positive regulation of cell proliferation (IMP, 18719127)   positive regulation of cell proliferation (IDA, 2261637)   humoral immune response (IC, 3491322)   inflammatory response (IDA, 10443688)   acute-phase response (TAS, 12832423)   positive regulation of leukocyte chemotaxis (IC, 16034137)   positive regulation of acute inflammatory response (IDA, 2444978)   monocyte chemotaxis (IC, 10510402)   neutrophil mediated immunity (IC, 16034137)   hepatic immune response (TAS, 12832423)   hepatic immune response (IDA, 2444978)   neutrophil apoptosis (IDA, 7595060)  
7 IL6 (human) AP-1
(unknown)
12727841 49 terms found
glucagon secretion (ISS, 18719127)   interleukin-6-mediated signaling pathway (IDA, 12552091)   defense response to virus (IDA, 3023045)   response to glucocorticoid stimulus (IDA, 10443688)   positive regulation of NF-kappaB transcription factor activity (IDA, 12419823)   positive regulation of transcription factor activity (IDA, 7749983)   positive regulation of immunoglobulin secretion (IDA, 3491322)   positive regulation of B cell activation (IDA, 3491322)   defense response to Gram-positive bacterium (IEP, 16034137)   defense response to Gram-negative bacterium (IEP, 16034137)   positive regulation of peptidyl-tyrosine phosphorylation (IDA, 7508917)   positive regulation of smooth muscle cell proliferation (IDA, 10510402)   positive regulation of JAK-STAT cascade (IDA, 12419823)   positive regulation of transcription from RNA polymerase II promoter (IDA, 7508917)   regulation of angiogenesis (IC, 8557680)   positive regulation of anti-apoptosis (IMP, 18719127)   positive regulation of translation (IDA, 16732314)   positive regulation of osteoblast differentiation (TAS, 12372336)   negative regulation of chemokine biosynthetic process   positive regulation of MAPKKK cascade (IDA, 7508917)   negative regulation of apoptosis (IDA, 7595060)   positive regulation of gene-specific transcription (IDA, 7749983)   regulation of apoptosis (IDA, 9949178)   positive regulation of tyrosine phosphorylation of Stat3 protein (IDA, 12643274)   positive regulation of T cell proliferation (IDA, 3130269)   positive regulation of peptidyl-serine phosphorylation (IDA, 7508917)   negative regulation of collagen biosynthetic process (IDA, 12419823)   positive regulation of interleukin-6 production (IDA, 10510402)   positive regulation of chemokine production (IMP, 16034137)   response to peptidoglycan (IEP, 16034137)   positive regulation of chemokine production (IDA, 10510402)   neuron projection development (IMP, 3264880)   endocrine pancreas development (ISS, 18719127)   platelet activation (TAS, 7831669)   cytokine-mediated signaling pathway (IDA, 12643274)   regulation of vascular endothelial growth factor production (IDA, 8557680)   negative regulation of cell proliferation (TAS, 3023045)   positive regulation of cell proliferation (IMP, 18719127)   positive regulation of cell proliferation (IDA, 2261637)   humoral immune response (IC, 3491322)   inflammatory response (IDA, 10443688)   acute-phase response (TAS, 12832423)   positive regulation of leukocyte chemotaxis (IC, 16034137)   positive regulation of acute inflammatory response (IDA, 2444978)   monocyte chemotaxis (IC, 10510402)   neutrophil mediated immunity (IC, 16034137)   hepatic immune response (TAS, 12832423)   hepatic immune response (IDA, 2444978)   neutrophil apoptosis (IDA, 7595060)  
8 IL6 (human) AP-1
(unknown)
19251936 49 terms found
glucagon secretion (ISS, 18719127)   interleukin-6-mediated signaling pathway (IDA, 12552091)   defense response to virus (IDA, 3023045)   response to glucocorticoid stimulus (IDA, 10443688)   positive regulation of NF-kappaB transcription factor activity (IDA, 12419823)   positive regulation of transcription factor activity (IDA, 7749983)   positive regulation of immunoglobulin secretion (IDA, 3491322)   positive regulation of B cell activation (IDA, 3491322)   defense response to Gram-positive bacterium (IEP, 16034137)   defense response to Gram-negative bacterium (IEP, 16034137)   positive regulation of peptidyl-tyrosine phosphorylation (IDA, 7508917)   positive regulation of smooth muscle cell proliferation (IDA, 10510402)   positive regulation of JAK-STAT cascade (IDA, 12419823)   positive regulation of transcription from RNA polymerase II promoter (IDA, 7508917)   regulation of angiogenesis (IC, 8557680)   positive regulation of anti-apoptosis (IMP, 18719127)   positive regulation of translation (IDA, 16732314)   positive regulation of osteoblast differentiation (TAS, 12372336)   negative regulation of chemokine biosynthetic process   positive regulation of MAPKKK cascade (IDA, 7508917)   negative regulation of apoptosis (IDA, 7595060)   positive regulation of gene-specific transcription (IDA, 7749983)   regulation of apoptosis (IDA, 9949178)   positive regulation of tyrosine phosphorylation of Stat3 protein (IDA, 12643274)   positive regulation of T cell proliferation (IDA, 3130269)   positive regulation of peptidyl-serine phosphorylation (IDA, 7508917)   negative regulation of collagen biosynthetic process (IDA, 12419823)   positive regulation of interleukin-6 production (IDA, 10510402)   positive regulation of chemokine production (IMP, 16034137)   response to peptidoglycan (IEP, 16034137)   positive regulation of chemokine production (IDA, 10510402)   neuron projection development (IMP, 3264880)   endocrine pancreas development (ISS, 18719127)   platelet activation (TAS, 7831669)   cytokine-mediated signaling pathway (IDA, 12643274)   regulation of vascular endothelial growth factor production (IDA, 8557680)   negative regulation of cell proliferation (TAS, 3023045)   positive regulation of cell proliferation (IMP, 18719127)   positive regulation of cell proliferation (IDA, 2261637)   humoral immune response (IC, 3491322)   inflammatory response (IDA, 10443688)   acute-phase response (TAS, 12832423)   positive regulation of leukocyte chemotaxis (IC, 16034137)   positive regulation of acute inflammatory response (IDA, 2444978)   monocyte chemotaxis (IC, 10510402)   neutrophil mediated immunity (IC, 16034137)   hepatic immune response (TAS, 12832423)   hepatic immune response (IDA, 2444978)   neutrophil apoptosis (IDA, 7595060)  
9 MMP1 (human) AP-1
(unknown)
14519134 4 terms found
10 MMP9 (human) AP-1
(unknown)
19208844 8 terms found
11 MMP9 (human) AP-1
(unknown)
4565943 8 terms found
12 MMP9 (human) AP-1
(unknown)
15608675 8 terms found
13 NQO1 (human) AP-1
(unknown)
8962164 8 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
There are no data available in this subsection.