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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

The current list of bonafide CLOCK:ARNTL target genes is fairly small, with evidence coming from a variety of experimental sources: the identification of the E-box within the gene's promoter, reduced mRNA leves in CLOCK- or ARNTL- mutant animals, chromatin immunopreciptiation assasys, reporter gene assays, and in vitro DNA binding assays (eg. EMSA). Some of the classical CLOCK:ARNTL targets, evidenced via several of the above approaches, include [gene name (Gene ID]): Per1 (18626), Per2 (8864), Cry1 (1407), Dbp (1628) and Nr1d1 (217166).

There are likely many other direct CLOCK:ARNTL target genes, and a searchable database of putative CLOCK:ARNTL targets can be found here: http://promoter.cdb.riken.jp/.

Of note, some CLOCK:ARNTL target genes may also be regulated by other transcription factors.

Targets (author curated)
  Target gene TF complex Effect References GO terms (biological process)
1 Avp (mouse) CLOCK:ARNTL
(none) 22 terms found
2 Cry1 (mouse) CLOCK:ARNTL
(none) 8 terms found
3 Dbp (mouse) CLOCK:ARNTL
(none) 6 terms found
4 Nr1d1 (mouse) CLOCK:ARNTL
(none) 5 terms found
5 Nr1d2 (mouse) CLOCK:ARNTL
(none) 4 terms found
6 Per1 (mouse) CLOCK:ARNTL
(none) 11 terms found
7 Per2 (mouse) CLOCK:ARNTL
(none) 7 terms found
8 Prok2 (mouse) CLOCK:ARNTL
(none) 3 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
  Target gene TF complex Effect References GO terms (biological process)
1 Dbp (mouse) pazar CLOCK_MOUSE/ARNTL_MOUSE
(unknown)
18252768 6 terms found
2 Per2 (mouse) pazar CLOCK_MOUSE/ARNTL_MOUSE
(unknown)
15699353 7 terms found