Recently visited
Please sign in to see a list of articles you recently visited.
Recently updated
Homo sapiens
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Mus musculus
Homo sapiens
Mus musculus
Transcription Factor Encyclopedia  BETA
Comments (post)
There are no comments posted here... Yet.

The Zic (zinc fingers in cerebellum) family of transcription factors comprises five members, Zic1-5, each of which has five C2H2 zinc finger domains. Fingers 2-5 are >85% conserved across the family, while the first zinc finger domain is unique to each Zic. Zic3 is the only unpaired member of the family and is located on the X chromosome, while the remaining four genes are found in two tightly linked, head to head pairs on two different autosomes (Zic1 plus Zic4 and Zic2 plus Zic5). The five Zic genes are highly conserved from mouse to human and mutant phenotypes have been identified in one or both species for all five genes[1]. During embryonic development,Zics are broadly expressed in overlapping patterns in the dorsal central nervous system and somites[2]. This, in conjunction with the high degree of zinc finger domain sequence similarity between the family members, suggests partial compensation of gene function in Zic mutants. Indeed, loss of function of each gene produces a distinct phenotype, but compound mutants may have abnormalities more severe than either single mutant[3][4]. While all Zic mutants display neural tube defects, additional abnormalities include holoprosencephaly, cerebellar malformation, laterality defects and congenital heart disease[1].

  1. Grinberg I and Millen KJ. The ZIC gene family in development and disease. Clin. Genet., 67(4):290-6. (PMID 15733262)
  2. Merzdorf CS. Emerging roles for zic genes in early development. Dev. Dyn., 236(4):922-40. (PMID 17330889)
  1. Aruga J et al. A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J. Neurochem., 63(5):1880-90. (PMID 7931345)
  2. Aruga J et al. Zic2 controls cerebellar development in cooperation with Zic1. J. Neurosci., 22(1):218-25. (PMID 11756505)
FIGURE 1 The ZIC family of transcription factors
The ZIC famly of transcription factors comprises five members in human and in mouse. Each family member has five C2H2 Zinc finger domains of which fingers 2-5 are highly conserved across the family (filled orange boxes) and the first zinc finger (orange patterned boxes) is unique to each member. The non-zinc finger domains of the protein are shown in black and white boxes represent 5' and 3' UTR. Zic1 and Zic4 are paired genes on human chromosome 3 and mouse chromosome 9, and Zic2 and Zic5 are paired on human and mouse chromosomes 13 and 14 respectively. Zic3 is found on the X chromosome in both species.
This figure was created by colleagues of the authors of this article. The authors of this article have provided the assurance that they have full permission to use this figure.