Recently visited
Please sign in to see a list of articles you recently visited.
Recently updated
 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
Comments (post)
There are no comments posted here... Yet.
Gene Ontology (automatically populated)
molecular_function (GO:0003674)
binding (GO:0005488)
nucleic acid binding (GO:0003676)
DNA binding (GO:0003677)
 sequence-specific DNA binding (GO:0043565
 protein binding (GO:0005515
ion binding (GO:0043167)
cation binding (GO:0043169)
transition metal ion binding (GO:0046914)
 zinc ion binding (GO:0008270
 metal ion binding (GO:0046872
transcription regulator activity (GO:0030528)
 transcription factor activity (GO:0003700
cellular_component (GO:0005575)
organelle (GO:0043226)
membrane-bounded organelle (GO:0043227)
intracellular membrane-bounded organelle (GO:0043231)
 nucleus (GO:0005634
biological_process (GO:0008150)
cellular process (GO:0009987)
cellular component movement (GO:0006928)
cell migration (GO:0016477)
 neuron migration (GO:0001764
 cell proliferation (GO:0008283
cellular component organization (GO:0016043)
extracellular structure organization (GO:0043062)
extracellular matrix organization (GO:0030198)
 collagen fibril organization (GO:0030199
cell development (GO:0048468)
neuron development (GO:0048666)
 central nervous system neuron development (GO:0021954
cellular developmental process (GO:0048869)
cell differentiation (GO:0030154)
 neuron differentiation (GO:0030182
multicellular organismal process (GO:0032501)
 multicellular organismal development (GO:0007275
developmental process (GO:0032502)
pattern specification process (GO:0007389)
regionalization (GO:0003002)
 dorsal/ventral pattern formation (GO:0009953
anatomical structure morphogenesis (GO:0009653)
 cerebellum morphogenesis (GO:0021587
embryonic development (GO:0009790)
embryonic development ending in birth or egg hatching (GO:0009792)
chordate embryonic development (GO:0043009)
 in utero embryonic development (GO:0001701
death (GO:0016265)
 cell death (GO:0008219
anatomical structure development (GO:0048856)
organ development (GO:0048513)
sensory organ development (GO:0007423)
eye development (GO:0001654)
 camera-type eye development (GO:0043010
growth (GO:0040007)
 organ growth (GO:0035265
biological regulation (GO:0065007)
regulation of biological process (GO:0050789)
regulation of cellular process (GO:0050794)
regulation of gene expression (GO:0010468)
regulation of transcription (GO:0045449)
 regulation of transcription, DNA-dependent (GO:0006355
positive regulation of transcription, DNA-dependent (GO:0045893)
 positive regulation of transcription from RNA polymerase II promoter (GO:0045944
 CategoryGO term IDTermEvidencePubmed
1BPGO:0043010camera-type eye developmentIEA(none)
2BPGO:0008219cell deathIEA(none)
3BPGO:0008283cell proliferationIEA(none)
4BPGO:0021954central nervous system neuron developmentIEA(none)
5BPGO:0021587cerebellum morphogenesisIEA(none)
6BPGO:0030199collagen fibril organizationIEA(none)
7BPGO:0009953dorsal/ventral pattern formationISS(none)
8BPGO:0001701in utero embryonic developmentNAS12792813
9BPGO:0007275multicellular organismal developmentNAS9590287
10BPGO:0030182neuron differentiationISS(none)
11BPGO:0001764neuron migrationIEA(none)
12BPGO:0035265organ growthIEA(none)
13BPGO:0045944positive regulation of transcription from RNA polymerase II promoterIEA(none)
14BPGO:0006355regulation of transcription, DNA-dependentIDA10767331
15CCGO:0005634nucleusIDA10767331
16MFGO:0046872metal ion bindingIEA(none)
17MFGO:0005515protein bindingIPI12792813
18MFGO:0043565sequence-specific DNA bindingIEA(none)
19MFGO:0003700transcription factor activityIDA10767331
20MFGO:0008270zinc ion bindingIEA(none)
MeSH cloud (automatically populated)
About this section
The MeSH cloud below displays MeSH terms that are associated with this transcription factor. The physical size of the terms reflect the significance of their association with the transcription factor as determined by the Fisher's Exact Test. It should be noted that these associations do not necessarily imply a positive correlation between the described MeSH term and this transcription factor. For instance, if the MeSH term "apoptosis" occurs, it may indicate that this transcription factor can induce apoptosis (positive correlation), or prevent apoptosis (negative correlation). Methods: The transcription factor is mapped to a set of Pubmed publications through the gene-to-pubmed association as provided by NCBI. Then, a collection of MeSH terms associated with the papers are compiled, along with the frequency of each MeSH term. The Fisher's Exact Test is conducted on the frequency of each term in the collection, versus its average frequency, to determine its significance in the collection. More information on MeSH can be found on the MeSH homepage.
MeSH term Fisher's exact p-value
1 Nail-Patella Syndrome 4.9 x 10-100
2 Homeodomain Proteins 1.9 x 10-89
3 DNA Mutational Analysis 2.0 x 10-22
4 Genes, Dominant 1.6 x 10-10
5 Promoter Regions, Genetic 2.6 x 10-10
6 Polymorphism, Single Nucleotide 1.2 x 10-9
7 Pedigree 1.4 x 10-9
8 Genetic Predisposition to Disease 3.8 x 10-8
9 Mice, Knockout 7.0 x 10-8
10 Transcription, Genetic 1.0 x 10-7
11 Kidney Glomerulus 2.4 x 10-7
12 Glaucoma, Open-Angle 4.7 x 10-7
13 Humans 5.6 x 10-7
14 Linkage (Genetics) 1.2 x 10-6
15 Family Health 3.2 x 10-6
16 Collagen Type IV 4.8 x 10-6
17 Frameshift Mutation 2.7 x 10-5
18 Genes, Homeobox 4.8 x 10-5
19 Chromosomes, Human, Pair 9 5.4 x 10-5
20 DNA, Complementary 0.00018
21 Nephrotic Syndrome 0.00023
22 Adolescent 0.00035
23 Open Reading Frames 0.00051
24 Haplotypes 0.00086
25 Transcriptional Activation 0.00089
26 Heteroduplex Analysis 0.0010
27 Gene Deletion 0.0011
28 Heterozygote 0.0013
29 Point Mutation 0.0014
30 Parkinson Disease 0.0018
31 Nephritis, Hereditary 0.0024
32 Gene Frequency 0.0026
33 Nails, Malformed 0.0026
34 TCF Transcription Factors 0.0031
35 Cell Differentiation 0.0036
36 Transcription Factor RelA 0.0038
37 Familial Mediterranean Fever 0.0041
38 Codon, Nonsense 0.0045
39 Talus 0.0047
40 Helix-Loop-Helix Motifs 0.0057
41 Haploidy 0.0065
42 Nails 0.0082
43 Tomography, Optical Coherence 0.0087
44 Repetitive Sequences, Nucleic Acid 0.0087
45 Protein Structure, Tertiary 0.0090
46 Interferon-beta 0.0092
47 Estrogen Receptor alpha 0.0096
48 Animals, Newborn 0.010
49 Sequence Homology, Amino Acid 0.010
50 Antisocial Personality Disorder 0.011
51 Plasmids 0.011
52 Reverse Transcriptase Polymerase Chain Reaction 0.011
53 Sus scrofa 0.012
54 Heterozygote Detection 0.012
55 Cricetinae 0.013
56 Two-Hybrid System Techniques 0.014
57 Mitochondrial Diseases 0.015
58 Zebrafish 0.015
59 Receptors, Androgen 0.015
60 Transfection 0.016
61 Body Patterning 0.017
62 Substantia Nigra 0.020
63 Mutation, Missense 0.020
64 Interleukin-8 0.021
65 Limb Deformities, Congenital 0.021
66 Alternative Splicing 0.024
67 Luciferases 0.024
68 Cytoskeletal Proteins 0.032
69 Genetic Testing 0.032
70 Homozygote 0.033
71 Protein Binding 0.035
72 Basement Membrane 0.035
73 DNA, Mitochondrial 0.039
74 Intraocular Pressure 0.041
75 Family 0.043
76 Proteinuria 0.046
77 In Situ Hybridization, Fluorescence 0.047
78 Gene Library 0.048
79 Blotting, Southern 0.049
MeSH term Fisher's exact p-value
1 Nail-Patella Syndrome 4.9 x 10-100
2 Homeodomain Proteins 1.9 x 10-89
3 Nail Diseases 4.3 x 10-72
4 Transcription Factors 2.2 x 10-56
5 DNA-Binding Proteins 6.1 x 10-55
6 Abnormalities, Multiple 1.3 x 10-48
7 Joint Diseases 1.0 x 10-36
8 Congenital Abnormalities 1.5 x 10-31
9 Genetic Diseases, Inborn 6.2 x 10-31
10 Genetic Variation 1.3 x 10-30
11 Genetic Phenomena 2.9 x 10-27
12 Skin Diseases 3.4 x 10-26
13 Musculoskeletal Diseases 8.6 x 10-26
14 Congenital, Hereditary, and Neonatal Diseases and Abnormalities 4.1 x 10-24
15 Skin and Connective Tissue Diseases 5.7 x 10-24
16 DNA Mutational Analysis 2.0 x 10-22
17 Proteins 1.1 x 10-20
18 Mutation 1.2 x 10-20
19 Sequence Analysis, DNA 2.9 x 10-19
20 Genetic Structures 8.7 x 10-19
21 Amino Acids, Peptides, and Proteins 9.7 x 10-19
22 Genetic Techniques 6.3 x 10-17
23 Sequence Analysis 6.8 x 10-17
24 Genes 1.3 x 10-16
25 Genome Components 7.0 x 10-16
26 Genome 1.7 x 10-15
27 Base Sequence 2.5 x 10-14
28 Gene Components 5.2 x 10-13
29 Genotype 1.3 x 10-12
30 Polymorphism, Genetic 1.5 x 10-12
31 Genes, Dominant 1.6 x 10-10
32 Molecular Structure 2.0 x 10-10
33 Promoter Regions, Genetic 2.6 x 10-10
34 Regulatory Elements, Transcriptional 4.6 x 10-10
35 Regulatory Sequences, Nucleic Acid 9.2 x 10-10
36 Polymorphism, Single Nucleotide 1.2 x 10-9
37 Pedigree 1.4 x 10-9
38 Inheritance Patterns 6.7 x 10-9
39 Phenotype 1.5 x 10-8
40 Gene Expression 2.7 x 10-8
41 Genetic Predisposition to Disease 3.8 x 10-8
42 Mice, Knockout 7.0 x 10-8
43 Mice, Mutant Strains 9.4 x 10-8
44 Transcription, Genetic 1.0 x 10-7
45 Genetic Processes 1.0 x 10-7
46 Molecular Sequence Data 1.2 x 10-7
47 Disease Susceptibility 1.7 x 10-7
48 Documentation 2.0 x 10-7
49 Kidney Glomerulus 2.4 x 10-7
50 Information Services 3.2 x 10-7
51 Kidney 3.9 x 10-7
52 Glaucoma, Open-Angle 4.7 x 10-7
53 Humans 5.6 x 10-7
54 Hominidae 5.7 x 10-7
55 Catarrhini 6.7 x 10-7
56 Kidney Cortex 7.1 x 10-7
57 Haplorhini 7.1 x 10-7
58 Primates 7.2 x 10-7
59 Biochemical Phenomena 7.6 x 10-7
60 Mice, Transgenic 1.1 x 10-6
61 Linkage (Genetics) 1.2 x 10-6
62 Genetic Code 1.3 x 10-6
63 Urinary Tract 1.5 x 10-6
64 Animals, Genetically Modified 1.8 x 10-6
65 Mice 3.0 x 10-6
66 Family Health 3.2 x 10-6
67 Organisms, Genetically Modified 3.5 x 10-6
68 Nucleic Acids 3.6 x 10-6
69 Nephrons 4.0 x 10-6
70 Collagen Type IV 4.8 x 10-6
71 Sequence Deletion 6.4 x 10-6
72 Polymerase Chain Reaction 6.8 x 10-6
73 Nucleic Acid Amplification Techniques 7.2 x 10-6
74 Nucleic Acids, Nucleotides, and Nucleosides 1.3 x 10-5
75 Chemical Phenomena 1.5 x 10-5
76 Codon, Terminator 2.5 x 10-5
77 Non-Fibrillar Collagens 2.6 x 10-5
78 Frameshift Mutation 2.7 x 10-5
79 Glaucoma 3.7 x 10-5
80 Mammals 3.7 x 10-5
81 Muridae 3.8 x 10-5
82 Ocular Hypertension 4.1 x 10-5
83 Genes, Homeobox 4.8 x 10-5
84 Genes, Developmental 5.1 x 10-5
85 Chromosomes, Human, Pair 9 5.4 x 10-5
86 Rodentia 6.3 x 10-5
87 Vertebrates 7.0 x 10-5
88 Chordata 7.0 x 10-5
89 Gene Expression Regulation 0.00015
90 Nucleic Acid Hybridization 0.00015
91 DNA Probes 0.00016
92 Animals 0.00018
93 DNA, Complementary 0.00018
94 Mutagenesis 0.00019
95 Urogenital System 0.00019
96 Investigative Techniques 0.00021
97 Nephrotic Syndrome 0.00023
98 In Situ Hybridization 0.00025
99 DNA, Single-Stranded 0.00031
100 Nucleic Acid Probes 0.00033
101 Adolescent 0.00035
102 Molecular Probes 0.00036
103 DNA 0.00038
104 Nephrosis 0.00039
105 Collagen 0.00040
106 Eukaryota 0.00042
107 Open Reading Frames 0.00051
108 Reading Frames 0.00054
109 Amino Acid Sequence 0.00058
110 Murinae 0.00059
111 Codon 0.00061
112 Haplotypes 0.00086
113 Transcriptional Activation 0.00089
114 Heteroduplex Analysis 0.0010
115 Gene Deletion 0.0011
116 Extracellular Matrix Proteins 0.0011
117 Heterozygote 0.0013
118 Point Mutation 0.0014
119 RNA 0.0014
120 RNA, Messenger 0.0015
121 Chromosomes, Human, 6-12 and X 0.0017
122 Parkinson Disease 0.0018
123 Staining and Labeling 0.0018
124 Urologic Diseases 0.0019
125 Scleroproteins 0.0020
126 Information Science 0.0020
127 Nephritis, Hereditary 0.0024
128 Gene Frequency 0.0026
129 Nails, Malformed 0.0026
130 Parkinsonian Disorders 0.0027
131 Kidney Diseases 0.0031
132 TCF Transcription Factors 0.0031
133 Cell Differentiation 0.0036
134 Transcription Factor RelA 0.0038
135 Familial Mediterranean Fever 0.0041
136 Hereditary Autoinflammatory Diseases 0.0041
137 Histocytological Preparation Techniques 0.0045
138 Codon, Nonsense 0.0045
139 Talus 0.0047
140 Health 0.0053
141 Disease Attributes 0.0054
142 Helix-Loop-Helix Motifs 0.0057
143 Basal Ganglia Diseases 0.0060
144 Biochemical Processes 0.0063
145 Haploidy 0.0065
146 Protein Conformation 0.0079
147 Nails 0.0082
148 Tomography, Optical Coherence 0.0087
149 Repetitive Sequences, Nucleic Acid 0.0087
150 Cytogenetic Analysis 0.0089
151 Protein Structure, Tertiary 0.0090
152 Interferon-beta 0.0092
153 Movement Disorders 0.0094
154 Male Urogenital Diseases 0.0096
155 Estrogen Receptor alpha 0.0096
156 Chromosomes, Human 0.0098
157 Tomography, Optical 0.0098
158 Chromosomes, Mammalian 0.010
159 Animals, Newborn 0.010
160 Sequence Homology, Amino Acid 0.010
161 Antisocial Personality Disorder 0.011
162 Plasmids 0.011
163 Reverse Transcriptase Polymerase Chain Reaction 0.011
164 Animal Population Groups 0.011
165 Sus scrofa 0.012
166 Heterozygote Detection 0.012
167 Cricetinae 0.013
168 High Mobility Group Proteins 0.013
169 Tarsal Bones 0.014
170 Two-Hybrid System Techniques 0.014
171 Female Urogenital Diseases 0.014
172 Mitochondrial Diseases 0.015
173 Zebrafish 0.015
174 Laboratory Chemicals 0.015
175 Receptors, Androgen 0.015
176 Intracellular Signaling Peptides and Proteins 0.016
177 Transfection 0.016
178 Histological Techniques 0.016
179 Foot Bones 0.017
180 Body Patterning 0.017
181 Molecular Conformation 0.019
182 Substantia Nigra 0.020
183 Mutation, Missense 0.020
184 Interleukin-8 0.021
185 Chemical Processes 0.021
186 Limb Deformities, Congenital 0.021
187 Sequence Homology 0.022
188 Alternative Splicing 0.024
189 Gene Transfer Techniques 0.024
190 Luciferases 0.024
191 Chromosomal Proteins, Non-Histone 0.026
192 Cells, Cultured 0.027
193 Eye Diseases 0.028
194 Collagen Diseases 0.028
195 Protein Interaction Mapping 0.029
196 Cloning, Molecular 0.029
197 Cytoskeletal Proteins 0.032
198 Genetic Testing 0.032
199 Neurodegenerative Diseases 0.032
200 Homozygote 0.033
201 Tegmentum Mesencephali 0.034
202 Chemokines, CXC 0.034
203 Protein Binding 0.035
204 Cyprinidae 0.035
205 Basement Membrane 0.035
206 Cypriniformes 0.035
207 DNA, Mitochondrial 0.039
208 Female Urogenital Diseases and Pregnancy Complications 0.040
209 Intraocular Pressure 0.041
210 Recombination, Genetic 0.042
211 Nuclear Proteins 0.043
212 Family 0.043
213 RNA Splicing 0.043
214 Amino Acid Motifs 0.045
215 Genetic Services 0.045
216 Proteinuria 0.046
217 Personality Disorders 0.046
218 In Situ Hybridization, Fluorescence 0.047
219 NF-kappa B 0.047
220 Chromosomes 0.047
221 Cytological Techniques 0.048
222 Gene Library 0.048
223 Blotting, Southern 0.049
 Adolescent   Alternative Splicing   Animals, Newborn   Antisocial Personality Disorder   Basement Membrane   Blotting, Southern   Body Patterning   Cell Differentiation   Chromosomes, Human, Pair 9   Codon, Nonsense   Collagen Type IV   Cricetinae   Cytoskeletal Proteins   DNA Mutational Analysis   DNA, Complementary   DNA, Mitochondrial   Estrogen Receptor alpha   Familial Mediterranean Fever   Family   Family Health   Frameshift Mutation   Gene Deletion   Gene Frequency   Gene Library   Genes, Dominant   Genes, Homeobox   Genetic Predisposition to Disease   Genetic Testing   Glaucoma, Open-Angle   Haploidy   Haplotypes   Helix-Loop-Helix Motifs   Heteroduplex Analysis   Heterozygote   Heterozygote Detection   Homeodomain Proteins   Homozygote   Humans   In Situ Hybridization, Fluorescence   Interferon-beta   Interleukin-8   Intraocular Pressure   Kidney Glomerulus   Limb Deformities, Congenital   Linkage (Genetics)   Luciferases   Mice, Knockout   Mitochondrial Diseases   Mutation, Missense   Nail-Patella Syndrome   Nails   Nails, Malformed   Nephritis, Hereditary   Nephrotic Syndrome   Open Reading Frames   Parkinson Disease   Pedigree   Plasmids   Point Mutation   Polymorphism, Single Nucleotide   Promoter Regions, Genetic   Protein Binding   Protein Structure, Tertiary   Proteinuria   Receptors, Androgen   Repetitive Sequences, Nucleic Acid   Reverse Transcriptase Polymerase Chain Reaction   Sequence Homology, Amino Acid   Substantia Nigra   Sus scrofa   Talus   TCF Transcription Factors   Tomography, Optical Coherence   Transcription Factor RelA   Transcription, Genetic   Transcriptional Activation   Transfection   Two-Hybrid System Techniques   Zebrafish