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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).

PLZF is recruited to specific sequences surrounding its target genes via its carboxy-terminal C2H2 zinc fingers and functions to repress transcription (or activate transcription in the case of phosphorylated PLZF in response to interferon treatment in NKT cells). PLZF targets genes involved in development, cell cycle, apoptosis and micoRNA genes. PLZF has been shown to bind to several different target genes and in most cases binding occurs within the proximal promoter region centered on an AT-rich sequence of 8 nucleotides. Many PLZF-target gene interactions most likely occur through multiple of 9 carboxy-terminal C2H2 zinc fingers. Sequence analysis and structural considerations suggest that zinc fingers 5 to 8 are most typical DNA binding fingers in that they containing a canonical TGEKP linker, and zinc fingers 6 to 8 may account best for the minimal PLZF target site 5'-TACTGTAC specificity. Additionally, PLZF may be recruited to target genes through protein-protein interactions with other transcription factors including Rb and the S phase promoting factor E2F1, or through nuclear repressor complex components such as HDAC1, mSin3a, SMRT and NCoR.

Targets (author curated)
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).
  Target gene TF complex Effect References GO terms (biological process)
1 BID (human) PLZF
(unknown)
14769944 8 terms found
2 CCNA2 (human) PLZF
(unknown)
10023668 10 terms found
3 CCNA2 (human) PLZF
(unknown)
10023668 10 terms found
4 CDC6 (human) PLZF E2F Rb
(unknown)
18504436 9 terms found
5 CRABP1 (human) PLZF
(unknown)
18000064 3 terms found
6 HOXB2 (human) PLZF
(unknown)
12802276 11 terms found
7 HOXD11 (human) PLZF
(unknown)
12408802 14 terms found
8 hsa-mir-146a (human) PLZF
(unknown)
18568019 (no terms found)
9 hsa-mir-221 (human) PLZF
(unknown)
18417445 (no terms found)
10 hsa-mir-222 (human) PLZF
(unknown)
18417445 (no terms found)
11 ITGA4 (human) PLZF
(unknown)
16158049 10 terms found
12 KIT (human) PLZF
(unknown)
17664282 28 terms found
13 MPL (human) PLZF GATA1
(unknown)
12242665 2 terms found
14 MYC (human) PLZF
(unknown)
14645547 11 terms found
15 PBX1 (human) PLZF
(unknown)
16862184 20 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
There are no data available in this subsection.