Recently visited
Please sign in to see a list of articles you recently visited.
Recently updated
 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
Comments (post)
There are no comments posted here... Yet.
Overview
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).

PLZF contains an amino-terminal BTB/POZ domain and 9 carboxy-terminal C2H2 zinc finger domains. PLZF forms homodimers and interacts with corepressors via its BTB/POZ domain, a highly conserved domain of approximately 100 amino acids present in greater than 200 human proteins. The BTB/POZ domain is frequently located at the amino-terminus and often exists in multiprotein transcription complexes. The crystal structure of the BTB/POZ domain of PLZF reveals a compact dimer with a large hydrophobic interface; where about one-quarter of the monomer surface area is involved in a dimer intermolecular contact. This is suggestive of an obligate PLZF homodimer, where the PLZF protein likely forms a branched transcription factor with two C-terminal DNA-binding regions. A surface exposed groove surrounded by conserved amino acids is present the dimer interface, forming a groove that may represent the site of interaction of the BTB/POZ domain with corepressors. Mutations in conserved residues involved in protein dimerization suggests that the composition of the dimer interface is sensitive to mutation and that dimer formation is required for normal levels of transcriptional repression.

The C2H2 Krüppel-type zinc fingers of PLZF are a type of DNA-binding domain, approximately 25–30 amino acids long, that are characterized by two conserved cysteine and histidine residue pairs that coordinate a single zinc atom, which serves as a crucial determinant of zinc finger conformation. An α-helix in each domain can make sequence specific contacts to DNA bases; residues from a single recognition helix can contact 3 to 4 bases.

Structures
About this section
This section contains 3D PDB models of structural predictions for this transcription factor. METHODS: The template selection protocol follows that of Morozov and Siggia, in which templates are selected to optimize similarity of DNA-binding residues (Morozov AV, Siggia ED. PNAS 104(17):7068-73). This has been shown to increase modeling accuracy at the DNA-binding interface. For all solved structures containing DNA, amino acids within 4A of DNA (DNA-binding residues) are stored. Pfam domain hits of each DNA-bound chain are detected by hmmer, and each hit is added to a list mapping domain family name to chain hits. Pfam domain hits of each unsolved structure are detected by HMMER. For each identified Pfam family, the unsolved sequence is aligned to all solved family members (putative templates). Alignments are scored based on similarity of the DNA-binding residues in the template to the aligned residues of the unsolved sequence. For each subsequence of the unsolved protein identified as a DNA-binding domain, the top scoring template is selected. For sequences known to form homodimers, a homodimeric template is selected. The model is constructed from the template using Modeller 9v2. DNA bound to the template is added to the model by superimposition of the solved and modeled structures.
Zbtb16 235320 zf C2H2 1a1hA
Image 3D Model .PDB File
Family
Zinc-coordinating Group » BetaBetaAlpha-zinc Finger Family
Bcl6
Mus musculus
Ctcf
Mus musculus
Egr1
Mus musculus
Egr2
Mus musculus
Egr3
Mus musculus
Egr4
Mus musculus
Evi1
Mus musculus
Gfi1
Mus musculus
Gli1
Mus musculus
Gli2
Mus musculus
Gli3
Mus musculus
Gtf3a
Mus musculus
 HIC1
Homo sapiens
 Hic1
Mus musculus
Hivep1
Mus musculus
Hivep2
Mus musculus
Ikzf1
Mus musculus
Ikzf3
Mus musculus
Klf1
Mus musculus
Klf10
Mus musculus
Klf12
Mus musculus
Klf13
Mus musculus
Klf15
Mus musculus
Klf16
Mus musculus
Klf4
Mus musculus
Klf5
Mus musculus
Klf7
Mus musculus
Klf9
Mus musculus
MAZ
Homo sapiens
Maz
Mus musculus
Mtf1
Mus musculus
Myt1
Mus musculus
Myt1l
Mus musculus
Mzf1
Mus musculus
Ovol1
Mus musculus
Ovol2
Mus musculus
Plag1
Mus musculus
Plagl1
Mus musculus
Prdm1
Mus musculus
Rest
Mus musculus
Rreb1
Mus musculus
Sall2
Mus musculus
Sall4
Mus musculus
Scrt1
Mus musculus
Snai1
Mus musculus
 SNAI2
Homo sapiens
 Snai2
Mus musculus
Snai3
Mus musculus
 Sp1
Mus musculus
Sp3
Mus musculus
Sp4
Mus musculus
Sp7
Mus musculus
Vezf1
Mus musculus
Wt1
Mus musculus
Yy1
Mus musculus
 Zbtb16
Mus musculus
Zbtb17
Mus musculus
Zbtb20
Mus musculus
 Zbtb33
Mus musculus
Zbtb7b
Mus musculus
Zeb1
Mus musculus
Zeb2
Mus musculus
Zfp110
Mus musculus
Zfp148
Mus musculus
Zfp161
Mus musculus
Zfp239
Mus musculus
Zfp263
Mus musculus
Zfp354a
Mus musculus
Zfp423
Mus musculus
Zfp467
Mus musculus
Zfp60
Mus musculus
Zfp668
Mus musculus
Zfp68
Mus musculus
Zfp90
Mus musculus
 ZIC1
Homo sapiens
 Zic1
Mus musculus
 ZIC2
Homo sapiens
 Zic2
Mus musculus
 ZIC3
Homo sapiens
 Zic3
Mus musculus
 ZIC4
Homo sapiens
 Zic4
Mus musculus
 ZIC5
Homo sapiens
 Zic5
Mus musculus
Zkscan17
Mus musculus
Zscan21
Mus musculus
 
Figures
There are no figures here... Yet.