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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).

PLZF mediates transcriptional repression through the recruitment of different corepressor molecules via its amino-terminal BTB/POZ domain. PLZF associated repressors form multiprotein complexes that include NCoR, SMRT, mSin3A, HDACs, as well as several other transcription factors.

PLZF forms homodimers and interacts with corepressors via its BTB/POZ domain, a highly conserved domain of approximately 100 amino acids present in greater than 200 human proteins. The BTB/POZ domain is frequently located at the amino-terminus and often exists in multiprotein transcription complexes. There is extensive contact between monomers at the dimer interface where conserved residues likely form specific interactions with the various nuclear corepressors. Mutations in conserved residues involved in protein dimerization suggests that the composition of the dimer interface is sensitive to mutation and that dimer formation is required for normal levels of transcriptional repression.

Many of the described interactions are from two-hybrid studies. Because PLZF is known to form large multiprotein complexes with nuclear corepressors, many of these interactions may indirect. These studies, however, may provide more insight into the transcriptional repression/activation role of PLZF.

Ligands (author curated)
There are no data here... Yet.
Interactions (author curated)
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).
  Interactor Experiment Types and Papers Nature of Interaction
1 GLI3 (human)
Phenotypic Enhancement
16015334
Genetic
Interactions (automatically populated)
There are no interaction data here... Yet.
Transcriptional regulators (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
There are no data here... Yet.