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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Genetics
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).

PLZF has functions during development and differentiation. Plzf is expressed in early, but not differentiated, hematopoietic cells, suggesting that Plzf is involved in stem cell maintenance and self renewal. Accordingly, PLZF regulates spermatogenesis, as PLZF null mice exhibit smaller testes, and a progressive loss of spermatogonia into adulthood relative to control littermates. PLZF appears to be antiapoptotic in the developing testis because null mice show an increase in apoptosis seminiferous tubule cells where spermatozoa maturation takes place. Plzf also regulates genes involved in cellular proliferation and differentiation. PLZF knockout mice exhibit defects in patterning of the limb and axial skeleton. PLZF influences limb development as a direct repressor of posterior HoxD genes. It was reported that a human patient with biallelic loss of function of the PLZF gene has severe skeletal defects and genital hypoplasia.

PLZF has a role in natural killer T (NKT) cell functions. PLZF-deficient NKT cells fail undergo an intra-thymic expansion and differentiation. Conversely, transgenic expression of PLZF induced CD4+ thymocytes to acquire effector differentiation and migrate to non-lymphoid tissues. Accordingly, it has been suggested that PLZF has a role in the transcriptional signature of NKT cells that directs their innate-like effector differentiation during thymic development. PLZF is highly expressed in undifferentiated hematopoietic progenitor cells and its expression declines as cells become more differentiated and committed to various hematopoietic lineages.

MeSH cloud (automatically populated)
About this section
The MeSH cloud below displays MeSH terms that are associated with this transcription factor. The physical size of the terms reflect the significance of their association with the transcription factor as determined by the Fisher's Exact Test. It should be noted that these associations do not necessarily imply a positive correlation between the described MeSH term and this transcription factor. For instance, if the MeSH term "apoptosis" occurs, it may indicate that this transcription factor can induce apoptosis (positive correlation), or prevent apoptosis (negative correlation). Methods: The transcription factor is mapped to a set of Pubmed publications through the gene-to-pubmed association as provided by NCBI. Then, a collection of MeSH terms associated with the papers are compiled, along with the frequency of each MeSH term. The Fisher's Exact Test is conducted on the frequency of each term in the collection, versus its average frequency, to determine its significance in the collection. More information on MeSH can be found on the MeSH homepage.
MeSH term Fisher's exact p-value
1 Leukemia, Promyelocytic, Acute 7.6 x 10-12
2 Translocation, Genetic 8.6 x 10-7
3 Abnormalities, Drug-Induced 0.00079
4 Alphavirus Infections 0.0073
5 Cell Transformation, Neoplastic 0.013
6 Genomic Instability 0.016
7 Mammary Neoplasms, Experimental 0.046
MeSH term Fisher's exact p-value
1 Leukemia, Promyelocytic, Acute 7.6 x 10-12
2 Leukemia, Myeloid, Acute 1.1 x 10-7
3 Translocation, Genetic 8.6 x 10-7
4 Leukemia, Myeloid 2.4 x 10-6
5 Chromosome Aberrations 3.1 x 10-5
6 Leukemia 0.00022
7 Abnormalities, Drug-Induced 0.00079
8 Alphavirus Infections 0.0073
9 Infertility 0.0090
10 Cell Transformation, Neoplastic 0.013
11 Genomic Instability 0.016
12 Togaviridae Infections 0.030
13 Mammary Neoplasms, Experimental 0.046
MGI mammalian phenotype terms (automatically populated)
No annotation is available in this section for this article. The content below is taken from a related TF, ZBTB16 (Homo sapiens).
abnormal axial skeleton morphology (MP:0002114) abnormal spermatogenesis (MP:0001156) abnormal fibula morphology (MP:0002187) abnormal tibia morphology (MP:0000558) ectopic digits (MP:0000568) oligodactyly (MP:0000565) polydactyly (MP:0000562) abnormal forelimb morphology (MP:0000550) abnormal hindlimb morphology (MP:0000556) short limbs (MP:0000547) kinked tail (MP:0000585) short tail (MP:0000592) Leydig cell hyperplasia (MP:0001152) small testis (MP:0001147) decreased caudal vertebrae number (MP:0001539) seminiferous tubule degeneration (MP:0001154) oligozoospermia (MP:0002687) asthenozoospermia (MP:0002675) abnormal spermatogonia proliferation (MP:0002685) increased circulating testosterone level (MP:0002781) abnormal talus morphology (MP:0005109) abnormal tarsal bone morphology (MP:0005104) abnormal patella morphology (MP:0005353) absent fibula (MP:0005430) vertebral transformation (MP:0003036) increased rib number (MP:0000480) abnormal metatarsal bone morphology (MP:0003072) testicular atrophy (MP:0003205) lumbar vertebral transformation (MP:0004616) sacral vertebral transformation (MP:0004617) thoracic vertebral transformation (MP:0004618) fused metatarsal bones (MP:0004642) increased thoracic vertebrae number (MP:0004651) xiphoid process foramen (MP:0004679) absent patella (MP:0004694) abnormal spermatogonia morphology (MP:0006378) increased diameter of fibula (MP:0008159) male germ cell apoptosis (MP:0008280) brachyphalangia (MP:0002543) short tibia (MP:0002764) long fibula (MP:0000482) polyphalangy (MP:0000413) increased presacral vertebrae number (MP:0000464) abnormal sternebra morphology (MP:0004322) bowed fibula (MP:0004372) azoospermia (MP:0005159) decreased male germ cell number (MP:0004901) male infertility (MP:0001925) abnormal digit morphology (MP:0002110) abnormal limb morphology (MP:0002109) hemimelia (MP:0008985)