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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

Among RAR target genes are various key regulators of differentiation, proliferation and apoptosis, reflecting the important roles of the RARs during embryonic development and maintenance of tissue homeostasis in the adult[1]. Examples of known targets are various Hox genes, retinoid metabolizing enzymes and binding proteins and specific RAR isoforms.[2][3]

Genome-wide binding sites of RARs have been characterized by ChIP-chip and ChIP-seq in the human breast cancer cell line MCF7 and have revealed an extensive overlap with estrogen receptor (ER) target sites.[4][5]

References
  1. Germain P et al. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol. Rev., 58(4):712-25. (PMID 17132850)
  2. Balmer JE and Blomhoff R. Gene expression regulation by retinoic acid. J. Lipid Res., 43(11):1773-808. (PMID 12401878)
  3. Balmer JE and Blomhoff R. A robust characterization of retinoic acid response elements based on a comparison of sites in three species. J. Steroid Biochem. Mol. Biol., 96(5):347-54. (PMID 16081280)
  1. Hua S et al. Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell, 137(7):1259-71. (PMID 19563758)
  2. Ross-Innes CS et al. Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer. Genes Dev., 24(2):171-82. (PMID 20080953)
Targets (author curated)
  Target gene TF complex Effect References GO terms (biological process)
1 BTG2 (human) RXRA/RARA
17234770 14 terms found
2 CASP9 (human) RXRA/RARA
16166294 4 terms found
3 Cdx1 (mouse) RXR/RARA
10938132 9 terms found
4 Foxa1 (mouse) RXR/RARA
10388516 25 terms found
5 GPRC5A (human) RXR/RARA
17239240 2 terms found
6 Hoxd4 (mouse) RXR/RARA
8093325 8 terms found
7 IER3 (human) PML-RARA
18039708 3 terms found
8 Rara (mouse) RXR/RARA
1658797 27 terms found
9 RARG (human) RXR/RARA
1320193 19 terms found
10 Rbp1 (mouse) RXR/RARA
1648481 7 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
  Target gene TF complex Effect References GO terms (biological process)
1 ABCC2 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 2 terms found
2 ADRB1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 13 terms found
3 ALDH1A1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 2 terms found
4 APOA1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 32 terms found
blood vessel endothelial cell migration   cholesterol import (IMP, 14718538)   positive regulation of transferase activity   positive regulation of hydrolase activity (IDA, 7638166)   negative regulation of hydrolase activity   protein stabilization (IDA, 17655203)   negative regulation of interleukin-1 beta secretion (IDA, 12458630)   reverse cholesterol transport (IMP, 15464323)   cholesterol homeostasis (IMP, 15464323)   lipoprotein biosynthetic process   high-density lipoprotein particle assembly (IDA, 190223)   high-density lipoprotein particle clearance (IC, 12651854)   high-density lipoprotein particle remodeling (IC, 4335615)   phospholipid efflux (IDA, 11162594)   cholesterol efflux (IDA, 14703508)   Cdc42 protein signal transduction (IDA, 16443932)   adrenal gland development   cholesterol transport (IDA, 10559507)   regulation of intestinal cholesterol absorption   lipid storage   positive regulation of cholesterol esterification (IDA, 4335615)   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 14967812)   cholesterol metabolic process (IMP, 15464323)   glucocorticoid metabolic process   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   lipid transport   phosphatidylcholine biosynthetic process (IDA, 4335615)   cholesterol biosynthetic process   phospholipid metabolic process   negative regulation of cytokine secretion during immune response (IDA, 12458630)   regulation of protein amino acid phosphorylation   endothelial cell proliferation  
5 APOC3 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 28 terms found
negative regulation of lipoprotein lipase activity (IDA, 18635818)   negative regulation of cholesterol import (IMP, 15778093)   triglyceride homeostasis (IMP, 18767813)   negative regulation of lipid catabolic process (IDA, 15576844)   negative regulation of receptor-mediated endocytosis (IDA, 1917954)   negative regulation of lipid metabolic process (IDA, 182536)   negative regulation of fatty acid biosynthetic process (IDA, 11060345)   cholesterol homeostasis (IMP, 18767813)   reverse cholesterol transport (IC, 15778093)   lipoprotein metabolic process   chylomicron remnant clearance (IDA, 4020294)   very-low-density lipoprotein particle assembly (TAS, 18399797)   high-density lipoprotein particle remodeling (IMP, 17438339)   cholesterol efflux (IDA, 16443932)   phospholipid efflux (IDA, 11162594)   Cdc42 protein signal transduction (IDA, 16443932)   triglyceride catabolic process (IDA, 11060345)   negative regulation of low-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of high-density lipoprotein particle clearance (IMP, 15778093)   negative regulation of very-low-density lipoprotein particle clearance (IDA, 1917954)   negative regulation of very-low-density lipoprotein particle remodeling (IDA, 3973011)   negative regulation of very-low-density lipoprotein particle remodeling (IC, 18635818)   negative regulation of triglyceride catabolic process (IDA, 3973011)   cholesterol metabolic process   G-protein coupled receptor protein signaling pathway (IDA, 16443932)   triglyceride mobilization   lipid transport   triglyceride metabolic process (IMP, 17142127)  
6 BTG2 (human) pazar RXR/RAR_HUMAN
RARA_HUMAN
(unknown)
17234770 14 terms found
7 CASP9 (human) pazar RARA_HUMAN
RXR/RAR_HUMAN
(unknown)
16166294 4 terms found
8 CDKN2D (human) pazar RXR/RAR_HUMAN
(unknown)
16322758 14 terms found
9 CDX1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 6 terms found
10 CEBPE (human) pazar RXR/RAR_HUMAN
(unknown)
10330422 7 terms found
11 CRABP2 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 6 terms found
12 CRYAB (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 21 terms found
13 CYP26A1 (human) pazar RXR/RAR_HUMAN
(unknown)
16053444 7 terms found
14 EPO (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 27 terms found
15 ETS1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 14 terms found
16 FGF8 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 13 terms found
17 Foxa1 (mouse) pazar RARA_HUMAN
RXR/RAR_MOUSE
(unknown)
16081280 25 terms found
18 FOXA1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 23 terms found
19 GPRC5A (human) pazar RARA_HUMAN
(unknown)
17239240 2 terms found
20 HOXA1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 14 terms found
21 HOXA4 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 5 terms found
22 HOXA7 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 11 terms found
23 HOXB1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 12 terms found
24 HOXB4 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 11 terms found
25 HOXB5 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 6 terms found
26 HOXD4 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 4 terms found
27 KRT18 (human) pazar RXR/RAR_HUMAN
(unknown)
7667273 5 terms found
28 MDK (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 7 terms found
29 MPO (human) pazar RXR/RAR_HUMAN
(unknown)
8662930 6 terms found
30 NES (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 4 terms found
31 NES (human) pazar NR2F1 (COUP-TF)_HUMAN
RXRA_HUMAN
RXR/RAR_HUMAN
(unknown)
10222142 4 terms found
32 PCK1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 8 terms found
33 PLAT (human) pazar RXR/RAR_HUMAN
(unknown)
7706255 13 terms found
34 RAI1 (human) pazar RARA_HUMAN
(unknown)
17239240 (no terms found)
35 RARA (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 20 terms found
36 RARB (human) pazar RARB_HUMAN
RXR/RAR_HUMAN
(unknown)
16081280 12 terms found
37 RARB (human) pazar RARA_HUMAN
(unknown)
2164682 12 terms found
38 RARG (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 19 terms found
39 RARRES1 (human) pazar RARA_HUMAN
(unknown)
17239240 1 terms found
40 RARRES3 (human) pazar RXR/RAR_HUMAN
(unknown)
15850806 1 terms found
41 Rbp1 (mouse) pazar RAR_HUMAN
RXR/RAR_MOUSE
(unknown)
16081280 7 terms found
42 RBP1 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 2 terms found
43 RXRG (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 4 terms found
44 SMYD5 (human) pazar RARA_HUMAN
(unknown)
17239240 1 terms found
45 TLX2 (human) pazar RXR/RAR_HUMAN
(unknown)
16081280 6 terms found