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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

All members of the RAR family of nuclear receptor interact with members of the RXR family to form heterodimers that bind DNA with high affinity. Interactions between the DNA binding domain are sufficient to confer selectivity of DNA binding.[1] The ligand binding domains of RARs interact with a variety of transcriptional coregulators. Corepressors NCoR and SMRT are bound in the absence of ligand while other corepressors such as NRIP1 and LCoR can be bound in the presence of ligand. Ligand also induces recruitment of coactivators, including histone acetyl-transferases NCOA1/2/3 and CBP/p300, histone methyl-transferases, ATP-dependent chromatin remodeling complexes, and of components of the mediator complex and basal transcription machinery.[2][3][4]. In addition, RARs interact with other transcription factors such as the AP1 complex, enabling recruitment of RARs to DNA via tethering and possibly formation of chromatin loops between RARs and other transcription factors bound to the promoter/enhancers of RA target genes.

References
  1. Mader S et al. The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificites of the DNA binding domains. EMBO J., 12(13):5029-41. (PMID 8262045)
  2. McKenna NJ and O'Malley BW. Combinatorial control of gene expression by nuclear receptors and coregulators. Cell, 108(4):465-74. (PMID 11909518)
  1. Rochette-Egly C and Germain P. Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs). , 7:e005. (PMID 19471584)
  2. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J., 10(9):940-54. (PMID 8801176)
Ligands (author curated)
  Ligand Experiment Types and Papers Nature of Interaction
1 Estradiol
CID 5757
Not specifiedRegulatory: increases expression of this TF
2 Tretinoin
CID 444795
Not specifiedPhysical: with co-activator affecting recruitment
3 Tretinoin
CID 444795
Not specifiedRegulatory: increases expression of this TF
Interactions (author curated)
  Interactor Experiment Types and Papers Nature of Interaction
1 EP300 (human)
Invitro
8779723
Physical: with co-activator affecting recruitment
2 FOS (human)
Invitro
2176152
Physical: with another TF
3 JUN (human)
Invitro
1648728
Physical: with another TF
4 NCOA1 (human)
Invitro
8754792
Physical: with co-activator affecting recruitment
5 NCOR1 (human)
Two-hybrid
9531570, 10336495
Physical: with co-repressor affecting recruitment
6 NRIP1 (human)
Two-hybrid
12403842
Physical: with co-repressor affecting recruitment
7 PML (human)
Reconstituted Complex
10610177
Genetic
8 RXRA (human)
Invitro
1310351
Physical: with another TF: complex binds DNA
9 RXRB (human)
Invitro
1310259
Physical: with another TF: complex binds DNA
10 RXRG (human)
Two-hybrid
16189514
Physical: with another TF: complex binds DNA
11 SP1 (human)
Reconstituted Complex
10361124
Physical: with another TF
Interactions (automatically populated)
  Interactor Experiment Types and Papers Nature of Interaction
1 ARNTL (TF) Reconstituted Complex
11439184
Physical: with another TF
2 BAG1 Reconstituted Complex, Two-hybrid
9642262
Competitive inhibition
3 CCND3 Affinity Capture-Western, Two-hybrid, Reconstituted Complex
12482873
Physical: with co-activator affecting recruitment
4 CLOCK (TF) Reconstituted Complex, Two-hybrid
11439184
Physical: with another TF
5 GADD45A Affinity Capture-Western
10872826
Physical: with co-activator affecting recruitment
6 Gadd45b Reconstituted Complex
10872826
Physical: with co-activator affecting recruitment
7 GADD45G Reconstituted Complex
10872826
Physical: with co-activator affecting recruitment
8 HDAC3 Reconstituted Complex
12943985
Physical: with co-repressor affecting recruitment
9 HDAC4 Reconstituted Complex
12943985
Physical: with co-repressor affecting recruitment
10 IRX4 (TF) Reconstituted Complex, Two-hybrid
11382777
Physical: with another TF
11 JUB Co-fractionation, Affinity Capture-Western, Reconstituted Complex
20133701
Physical: with co-repressor affecting recruitment
12 KAT2B Affinity Capture-Western
14581481
Physical: with co-activator affecting recruitment
13 KDM5A Reconstituted Complex
11358960
Physical: with co-activator affecting recruitment
14 LIMD1 Affinity Capture-Western
20133701
Physical: with co-repressor affecting recruitment
15 MECR Two-hybrid
9795230
Physical: undefined direct interaction
16 NCOA2 Two-hybrid
12612084
Physical: with co-activator affecting recruitment
17 NCOA6 Two-hybrid, Reconstituted Complex
11158331, 10567404, 10823961
Physical: with co-activator affecting recruitment
18 NCOR1 Reconstituted Complex, Two-hybrid
9531570, 10336495
Physical: with co-repressor affecting recruitment
19 NCOR2 Reconstituted Complex, Affinity Capture-Western
9256429, 11929748
Physical: with co-repressor affecting recruitment
20 NKX2-1 (TF) Two-hybrid
10617585
Physical: with another TF
21 NPAS2 (TF) Two-hybrid, Reconstituted Complex
11439184
Physical: with another TF
22 NR0B2 Reconstituted Complex, Two-hybrid
9773978, 8650544
Physical: with co-repressor affecting recruitment
23 Nr0b2 Two-hybrid
8650544
Physical: with co-repressor affecting recruitment
24 NR2E3 (TF) Reconstituted Complex
10611353
Physical: with another TF
25 NR4A2 Two-hybrid, Reconstituted Complex
7705655
Not specified
26 NRBF2 Two-hybrid
10786636
Physical: with co-activator affecting recruitment
27 NRIP1 Reconstituted Complex, Affinity Capture-Western
12549917, 8887632, 14581481
Physical: with co-activator affecting recruitment
Physical: with co-repressor affecting recruitment
28 Nsd1 Two-hybrid, Reconstituted Complex
9628876
Physical: with co-activator affecting recruitment
Physical: with co-repressor affecting recruitment
29 PML Reconstituted Complex
10610177
Genetic
30 POU2F1 (TF) Reconstituted Complex
10480874
Physical: with another TF
31 RARA Reconstituted Complex
14521715
Not specified
32 RXRA (TF) Co-purification, Reconstituted Complex
1314167, 12052862
Physical: with another TF: complex binds DNA
33 RXRB (TF) Two-hybrid
16189514
Physical: with another TF: complex binds DNA
34 RXRG (TF) Two-hybrid
16189514
Physical: with another TF: complex binds DNA
35 SKI Affinity Capture-Western
19341714
Physical: with co-repressor affecting recruitment
36 SP1 (TF) Reconstituted Complex
10361124
Physical: with another TF
37 SRC Two-hybrid, Reconstituted Complex
12612084, 10454579
Physical: with co-activator affecting recruitment
38 TADA3L Reconstituted Complex, Phenotypic Enhancement, Affinity Capture-Western
12235159
Physical: with co-activator affecting recruitment
39 TDG Reconstituted Complex
12874288
Physical: with co-activator affecting recruitment
40 TRIM24 Reconstituted Complex
9115274
Physical: with co-activator affecting recruitment
41 TRIP4 Reconstituted Complex
10454579
Physical: with co-activator affecting recruitment
42 WTIP Affinity Capture-Western
20133701
Physical: with co-repressor affecting recruitment
43 ZBTB16 (TF) Reconstituted Complex, Two-hybrid
14521715
Competitive inhibition
Physical: with another TF
Transcriptional regulators (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
  Regulating TF complex Regulating TF Genomic links GO terms (biological process) Pubmed
1
RXR/RAR_HUMAN
TF0000788
RARA
Homo sapiens
ENSG00000131759
5914 (Entrez Gene)
20 terms found 16081280
2
RXR/RAR_HUMAN
TF0000788
RXRA
Homo sapiens
ENSG00000186350
6256 (Entrez Gene)
(no terms found) 16081280