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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

Patterns of expression of human RARalpha in the embryo and adult are consistent with the role of RA in development and tissue homeostasis.[1] RARalpha1 is transcriptionally up-regulated by the estrogen receptor alpha (ERa),[2][3] which may contribute to the higher sensitivity of ERalpha-positive breast tumors to RA. RARA location on chromosome 17q21 leads to co-amplification of RARA in a fraction of HER2- amplified breast tumors.[4] On the other hand, RARA promoters can be inactivated by hypermethylation in some cancers.[5]

References
  1. Germain P et al. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol. Rev., 58(4):712-25. (PMID 17132850)
  2. Laganière J et al. Functional genomics identifies a mechanism for estrogen activation of the retinoic acid receptor alpha1 gene in breast cancer cells. Mol. Endocrinol., 19(6):1584-92. (PMID 15831516)
  3. van der Leede BJ et al. Retinoic acid receptor alpha 1 isoform is induced by estradiol and confers retinoic acid sensitivity in human breast cancer cells. Mol. Cell. Endocrinol., 109(1):77-86. (PMID 7789618)
  1. Arriola E et al. Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines. Lab. Invest., 88(5):491-503. (PMID 18332872)
  2. Farias EF et al. Retinoic acid receptor alpha2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells. Cell Growth Differ., 13(8):335-41. (PMID 12193472)
Expression (automatically populated)
GNF Expression Atlas 2 Data from U133A and GNF1H Chips
Using GNF ID 203749_s_at that is linked to Ensembl Transcript ID ENST00000394089
1. Fetal brain
-15 
2. Whole brain
-23 
 
3. Temporal lobe
-38 
4. Parietal lobe
-9 
5. Occipital lobe
-46 
6. Prefrontal cortex
-30 
7. Cingulate cortex
7 
8. Cerebellum
-1 
9. Cerebellum peduncles
-5 
10. Amygdala
-25 
11. Hypothalamus
-62 
12. Thalamus
-10 
13. Subthalamic nucleus
-49 
14. Caudate nucleus
-36 
15. Globus pallidus
-38 
16. Olfactory bulb
12 
17. Pons
-36 
18. Medulla oblongata
-25 
 
19. Spinal cord
-6 
20. Ciliary ganglion
-18 
21. Trigeminal ganglion
7 
22. Superior cervical ganglion
-46 
23. Dorsal root ganglion
-22 
 
24. Thymus
0 
25. Tonsil
-8 
26. Lymph node
-10 
27. Bone marrow
5 
28. BM-CD71+ early erythroid
-91 
29. BM-CD33+ myeloid
55 
30. BM-CD105+ endothelial
-25 
31. BM-CD34+
35 
32. Whole blood
100 
 
33. PB-BDCA4+ dentritic cells
35 
34. PB-CD14+ monocytes
61 
35. PB-CD56+ NKCells
45 
36. PB-CD4+ Tcells
5 
37. PB-CD8+ Tcells
15 
38. PB-CD19+ Bcells
20 
 
39. Leukemia lymphoblastic (molt4)
-63 
40. 721 B lymphoblasts
49 
41. Lymphoma Burkitts Raji
19 
42. Leukemia promyelocytic (hl60)
-23 
43. Lymphoma Burkitts Daudi
-5 
44. Leukemia chronic myelogenous (k562)
7 
45. Colorectal adenocarcinoma
1 
 
46. Appendix
5 
47. Skin
-13 
48. Adipocyte
7 
49. Fetal thyroid
1 
50. Thyroid
-12 
51. Pituitary gland
12 
 
52. Adrenal gland
22 
53. Adrenal cortex
17 
54. Prostate
11 
55. Salivary gland
-42 
56. Pancreas
-21 
57. Pancreatic islets
1 
 
58. Atrioventricular node
-67 
59. Heart
-2 
60. Cardiac myocytes
3 
61. Skeletal muscle
23 
62. Tongue
-39 
63. Smooth muscle
-51 
64. Uterus
-25 
65. Uterus corpus
-52 
66. Trachea
-2 
 
67. Bronchial epithelial cells
2 
68. Fetal lung
6 
69. Lung
44 
 
70. Kidney
10 
71. Fetal liver
-33 
72. Liver
0 
73. Placenta
7 
 
74. Testis
19 
75. Testis Leydig cell
11 
76. Testis germ cell
-2 
77. Testis interstitial
2 
78. Testis seminiferous tubule
11 
79. Ovary
-6 
Mouse Brain Expression Data from Allen Brain Atlas