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Overview

Mice lacking Nfic exhibit apparently normal embryogenesis but have severe defects in postnatal tooth development. These defects include aberrant incisor development with thin and weakened incisor structure and a failure of normal molar root formation. The crowns of the molars appear normal but the roots fail to grow out of the crowns, likely due to a failure of the normal differentiation of the odontoblasts which form the root structure. Nfic has also been implicated in mammary gland development although Nfic-/- females can rear pups.

Figures
FIGURE 1 Fig. 1. Abnormal maxillary incisors of Nfic-/- mice.
A. Close view of maxillary incisors in situ of a P135 Nfic+/- male reared on standard chow. Black bar indicates thickness of the right maxillary incisor. B. Same as A except individual is a Nfic-/- littermate. Note the incisor is thin compared to A. C. Upper portion of an H&E stained coronal section of the head of a P135 Nfic+/+ male. Tongue is at bottom. Box locates right maxillary incisor. D. Same as C except individual is a Nfic-/- littermate. E. Magnified view of boxed area in C. Arrowhead and arrow indicate enamel & dentin, respectively. Note uniform layer of dentin around the circumference of the incisor. F. Magnified view of boxed area in D. Arrowhead indicates enamel deposition at the labial side whereas arrow indicates absence of dentin at the lingual side of the incisor. Copyright © American Society for Microbiology, Mol. Cell. Biol. Vol. 23, No. 3, p. 1075-1084, 2003.
This figure was created by the authors of this article. The authors of this article have provided the assurance that this figure constitutes their original work.