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Homo sapiens
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Homo sapiens
Mus musculus
Mus musculus
Homo sapiens
Mus musculus
Transcription Factor Encyclopedia  BETA
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NFIC was one of the first mammalian transcription factors cloned and was named CTF1 (for CAAT box transcription factor 1) by the lab that cloned it. It was later shown to be a member of the NFI gene family. It was the first transcription factor in which a "proline rich" transactivation domain was discovered and in some members this C-terminal domain contains a perfect repeat of the heptamer sequence found in the CTD of RNA polymerase II. While the NFIC CTD repeat has been shown to function as a transactivation domain in yeast (which do not express any endogenous NFI proteins), some isoforms of NFIC do not contain this repeat yet still function effectively as transcriptional activators. NFIC is O-glycosylated, the function of which is unknown.

Most of what is known about the biological roles of NFIC has been determined from the phenotype of Nfic-/- mice. These mice develop relatively normally during embryogenesis but have severe defects in postnatal tooth development, including dysgenesis of the incisors and a failure of the roots of the molars to grow out from the crowns.

See NFIA for a general description of the NFI gene family.

No annotation is available in this section for this article. The content below is taken from a related TF, NFIA (Homo sapiens).
FIGURE 1 Figure 1. CNS and Urinary Tract Defects in Five Individuals with 1p31.3 Rearrangements
From Lu et al. PLOS Genetics, Vol. 3, Issue 5, e80. (A-J) Brain CT or MRI show a thin corpus callosum in DGAP104 (arrow in A), DGAP089 (arrow in C), and DGAP205-1 (arrow in G); and agenesis of the corpus callosum in DGAP174 (asterisk in E) and DGAP205-1s (asterisk in I). Chiari type I malformation, a downward displacement of the tip of the cerebellar tonsils below the foramen magnum, was found in DGAP104 (arrowhead in A), DGAP174 (arrowhead in E), and DGAP205-1s (arrowhead in I). Congenital ventriculomegaly is present in DGAP089 (D), DGAP174 (F), and DGAP205-1s (J), and hydrocephalus was found in DGAP104 (B) and DGAP205-1 (H). An occipital shunt (arrow in B) was placed in DGAP104 to relieve severe hydrocephalus. (K) DGAP104 MRI shows a tethered spinal cord, with the extremity of the conus medullaris (arrow) at the level of the L4 vertebral body. Arrowhead shows a fishhook deformity of the lower sacral and coccygeal vertebrae. (L) VCUG of DGAP104 depicts left vesicoureteral reflux with retrograde tracking of dye through the ureter into the renal pelvis (arrow) and a right diverticulum at the ureterovesical junction (arrowhead). (M) Spine MRI of DGAP205-1 shows a tethered spinal cord with conus lying at the L3/L4 level (arrow). (N) VCUG of DGAP205-1 shows left vesicoureteral reflux (arrow). (O) Spine MRI of DGAP205-1s depicts a tethered spinal cord with conus lying at L5 (arrow).
This figure was created by the authors of this article. The authors of this article have provided the assurance that this figure constitutes their original work.