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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Isoforms
No annotation is available in this section for this article. The content below is taken from a related TF, NFIA (Homo sapiens).

Each of the 4 NFI genes in mammals are differentially spliced, resulting in as many as a dozen isoforms for each family member. Since the proteins can form both homo- and hetero-dimers, a multitude of specific isoforms are possible.

Covalent modifications
No annotation is available in this section for this article. The content below is taken from a related TF, NFIA (Homo sapiens).

NFI proteins are known to be covalently modified by glycosylation and phosphorylation. While a number of glyco- and phospho- forms have been identified, there is no evidence for specific biological functions of these modifications [1]. Tyrosine phoshorylation has been detected in the C-terminal transactivation domain of NFIX and appears to affect nuclear localization of the protein in some instances [2]. Effects on transcriptional modulation need to be performed to determine the biological significance of such phosporylation.

References
  1. Gronostajski RM. Roles of the NFI/CTF gene family in transcription and development. Gene, 249(1-2):31-45. (PMID 10831836)
  1. Singh U et al. A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. PLoS ONE, 4(4):e5050. (PMID 19337383)