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 SOX9
Homo sapiens
 HIF1A
Homo sapiens
 Pax6
Mus musculus
 PAX6
Homo sapiens
 Snai2
Mus musculus
 PPARA
Homo sapiens
 Ppara
Mus musculus
 Thrb
Mus musculus
 SNAI2
Homo sapiens
 Tbr1
Mus musculus
Transcription Factor Encyclopedia  BETA
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Overview

Among RAR target genes are various key regulators of differentiation, proliferation and apoptosis, reflecting the important roles of the RARs during embryonic development and maintenance of tissue homeostasis in the adult[1]. Examples of known targets are various Hox genes, retinoid metabolizing enzymes and binding proteins and specific RAR isoforms [2][3].

Genome-wide binding sites of RARs have been characterized by ChIP-chip and ChIP-seq in the human breast cancer cell line MCF7 and have revealed an extensive overlap with estrogen receptor (ER) target sites [4][5].

References
  1. Germain P et al. International Union of Pharmacology. LX. Retinoic acid receptors. Pharmacol. Rev., 58(4):712-25. (PMID 17132850)
  2. Balmer JE and Blomhoff R. Gene expression regulation by retinoic acid. J. Lipid Res., 43(11):1773-808. (PMID 12401878)
  3. Balmer JE and Blomhoff R. A robust characterization of retinoic acid response elements based on a comparison of sites in three species. J. Steroid Biochem. Mol. Biol., 96(5):347-54. (PMID 16081280)
  1. Hua S et al. Genomic antagonism between retinoic acid and estrogen signaling in breast cancer. Cell, 137(7):1259-71. (PMID 19563758)
  2. Ross-Innes CS et al. Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer. Genes Dev., 24(2):171-82. (PMID 20080953)
Targets (author curated)
  Target gene TF complex Effect References GO terms (biological process)
1 Cdx1 (mouse) RXR/RARA
10938132 9 terms found
2 Foxa1 (mouse) RXR/RARA
10388516 25 terms found
3 Hoxd4 (mouse) RXR/RARA
8093325 8 terms found
4 Rara (mouse) RXR/RARA
1658797 27 terms found
5 RARG (human) RXR/RARA
1320193 19 terms found
6 Rbp1 (mouse) RXR/RARA
1648481 7 terms found
Targets (automatically populated)
About this section
Data found in this section is cached from PAZAR, a public database of transcription factor and regulatory sequence annotation. Visit PAZAR at http://www.pazar.info/.
  Target gene TF complex Effect References GO terms (biological process)
1 Abcc2 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 7 terms found
2 Adrb1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 15 terms found
3 Aldh1a1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 15 terms found
4 Apoa1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 31 terms found
5 Apoc3 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 10 terms found
6 Cdx1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 9 terms found
7 Crabp2 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 3 terms found
8 Cryab (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 19 terms found
9 Cyp26a1 (mouse) pazar RARG_MOUSE
RXR/RAR_MOUSE
(unknown)
10976925 9 terms found
10 Epo (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 9 terms found
11 Ets1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 11 terms found
12 Fgf8 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 54 terms found
cell migration involved in mesendoderm migration (IMP, 10421635)   branching involved in salivary gland morphogenesis (IGI, 15042696)   branching involved in salivary gland morphogenesis (IMP, 15063181)   lung morphogenesis (IMP, 10411502)   thyroid stimulating hormone secreting cell differentiation (IDA, 9463347)   adrenocorticotropin hormone secreting cell differentiation (IDA, 9463347)   positive regulation of cell division   forebrain morphogenesis (IMP, 16613831)   generation of neurons (IMP, 16267092)   positive regulation of mitosis (IDA, 12783783)   cell fate commitment (IGI, 15809037)   negative regulation of neuron apoptosis (IMP, 16245339)   negative regulation of apoptosis (IMP, 16720880)   negative regulation of apoptosis (IGI, 16245339)   regulation of odontogenesis of dentine-containing tooth (IGI, 9244299)   inner ear morphogenesis (IGI, 15809037)   embryonic hindlimb morphogenesis (IGI, 16245339)   limb morphogenesis (IGI, 15328019)   embryonic heart tube development (IMP, 16720879)   dorsal/ventral axon guidance   male genitalia development (IDA, 12783783)   lung development (IMP, 10411502)   central nervous system neuron development   cell proliferation in forebrain (IMP, 16613831)   forebrain neuron development   forebrain dorsal/ventral pattern formation (IMP, 16613831)   pallium development (IMP, 16613831)   subpallium development (IMP, 16613831)   telencephalon development (IMP, 16613831)   positive regulation of gene expression (IDA, 9244299)   positive regulation of gene expression (IGI, 9847236)   positive regulation of gene expression (IMP, 10411502)   fibroblast growth factor receptor signaling pathway   embryonic development ending in birth or egg hatching (IMP, 14623825)   fibroblast growth factor receptor signaling pathway (IMP, 16245339)   fibroblast growth factor receptor signaling pathway (IDA, 10381577)   positive regulation of cell proliferation (IMP, 16720880)   positive regulation of cell proliferation (IGI, 16245339)   positive regulation of cell proliferation (IDA, 10381577)   mesodermal cell migration (IMP, 10421635)   motor axon guidance   heart development (IMP, 16720880)   apoptosis (IMP, 16613831)   determination of left/right symmetry (IMP, 10411502)   response to oxidative stress   heart morphogenesis (IMP, 16696966)   blood vessel remodeling (IGI, 17000704)   neural plate morphogenesis (IMP, 16613831)   heart looping (IMP, 10411502)   kidney development (IMP, 16049111)   induction of an organ (IGI, 15741321)   MAPKKK cascade (IMP, 16720880)   patterning of blood vessels (IGI, 15996652)   branching involved in ureteric bud morphogenesis (IMP, 16049111)  
13 Foxa1 (mouse) pazar RARA_HUMAN
RXR/RAR_MOUSE
(unknown)
16081280 25 terms found
14 Hoxa1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 23 terms found
15 Hoxa4 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 9 terms found
16 Hoxa7 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 10 terms found
17 Hoxb1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 13 terms found
18 Hoxb4 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 16 terms found
19 Hoxb5 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 11 terms found
20 Hoxd4 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 8 terms found
21 Mdk (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 7 terms found
22 Nes (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 2 terms found
23 Pck1 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 6 terms found
24 Pcp2 (mouse) pazar RARA/RXRA_MOUSE
(unknown)
9224660 1 terms found
25 Rara (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 27 terms found
26 Rarb (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 17 terms found
27 Rarb (mouse) pazar RARA_MOUSE
(unknown)
2164682 17 terms found
28 Rarg (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 26 terms found
29 Rbp1 (mouse) pazar RAR_HUMAN
RXR/RAR_MOUSE
(unknown)
16081280 7 terms found
30 Rbp2 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 2 terms found
31 Rbp2 (mouse) pazar RARA_MOUSE
(unknown)
8288643 2 terms found
32 Ren1 (mouse) pazar RARA_MOUSE
(unknown)
12591615 11 terms found
33 Rxrg (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 2 terms found
34 Tlx2 (mouse) pazar RXR/RAR_MOUSE
(unknown)
16081280 7 terms found